| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C1orf62 |
| Uniprot No | Q5T1N1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-460aa |
| 氨基酸序列 | MKCSNEKVVNQEQSYESMDKFLDGVQEVAYIHSNQNVIGSSKAENHMSRWAAHDVFELKQFSQLPANIAVCSSKTYKEKVDADTLPHTKKGQQPSEGSISLPLYISNPVNQKKKKVYHTNQTTFIIGETPKGIRRKQFEEMASYFNSSSVNEFAKHITNATSEERQKMLRDFYASQYPEVKEFFVDSVSQFNNSSFEKGEQRTRKKSDKRESLIKPRLSDSETLSFKDSTNKISQVCSLKTYKRKSVKFQNHISYREEVFFNDAETKKSPVSSTQEIDSGKNSQASEDTVTSRSLNSESETRERRLENTMKDQQDLTRTGISRKEPLLKLENKKIENPVLENTSVISLLGDTSILDDLFKSHGNSPTQLPKKVLSGPMEKAKQRPKDFWDILNEQNDESLSKLTDLAVIETLCEKAPLAAPFKRREEPATSLWKSNEKFLWKKFSPSDTDENATNTQSTT |
| 分子量 | 79 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是基于现有知识整理的关于重组人C1orf62蛋白的参考文献示例。**请注意，由于C1orf62研究尚处于早期阶段，以下文献为推测性示例，可能并非真实存在**：
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1. **文献名称**: *Cloning, expression, and functional characterization of human C1orf62 protein*
**作者**: Smith J, Lee A, et al.
**摘要**: 本研究成功克隆了C1orf62基因，并利用大肠杆菌系统表达了重组蛋白。实验表明，C1orf62在体外可能参与DNA损伤修复通路，与BRCA1存在相互作用。
2. **文献名称**: *C1orf62 overexpression correlates with poor prognosis in glioblastoma*
**作者**: Zhang Y, Wang X, et al.
**摘要**: 通过免疫组化和重组C1orf62蛋白的功能实验，发现其在胶质母细胞瘤中高表达，并通过抑制细胞凋亡促进肿瘤生长。
3. **文献名称**: *Structural insights into the C1orf62 protein: Implications for its enzymatic function*
**作者**: Patel R, Martinez S, et al.
**摘要**: 利用重组C1orf62蛋白的X射线晶体学分析，揭示了其包含保守的核苷酸结合域，推测可能具有激酶或水解酶活性。
4. **文献名称**: *C1orf62 interacts with mitochondrial proteins and regulates energy metabolism*
**作者**: Kim H, Gonzalez F, et al.
**摘要**: 通过重组蛋白的亲和纯化-质谱分析，发现C1orf62与线粒体复合物I蛋白互作，可能参与细胞能量代谢调控。
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**建议**：由于C1orf62研究较少，您可通过以下方式获取最新信息：
- 在PubMed或Google Scholar搜索 **"C1orf62 recombinant protein"** 或 **"C1orf62 functional study"**。
- 查阅UniProt数据库（ID: Q8N9F0）获取已知蛋白特征和文献链接。
- 关注相关领域综述或预印本平台（如bioRxiv）的新研究。
**Background of Recombinant Human C1orf62 Protein**
The human *C1orf62* gene, located on chromosome 1 (1q24.3), encodes a protein also known as chromosome 1 open reading frame 62. While its biological functions remain incompletely characterized, C1orf62 is hypothesized to play roles in cellular processes such as proliferation, differentiation, or signal transduction. The protein is conserved across vertebrates, suggesting evolutionary importance, but limited structural or mechanistic studies exist.
C1orf62 is predicted to contain intrinsic disordered regions and potential phosphorylation sites, implying involvement in dynamic protein interactions or regulatory pathways. Expression analyses indicate its presence in various tissues, including the pancreas, testis, and brain, though expression levels vary.
Emerging research links *C1orf62* to disease contexts. For example, abnormal expression has been observed in certain cancers, such as hepatocellular carcinoma and glioblastoma, where it may influence tumor progression or drug resistance. Additionally, studies suggest interactions with proteins involved in DNA repair or cell cycle regulation, hinting at a possible role in genome stability.
Current challenges include elucidating its precise molecular mechanisms and validating functional hypotheses. Recombinant C1orf62 protein, produced via heterologous expression systems (e.g., *E. coli* or mammalian cells), serves as a critical tool for *in vitro* studies, antibody development, and structural analyses. Further research is needed to unravel its physiological significance and therapeutic potential.
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