| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C1orf163 |
| Uniprot No | Q96BR5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-231aa |
| 氨基酸序列 | MAGMVDFQDEEQVKSFLENMEVECNYHCYHEKDPDGCYRLVDYLEGIRKNFDEAAKVLKFNCEENQHSDSCYKLGAYYVTGKGGLTQDLKAAARCFLMACEKPGKKSIAACHNVGLLAHDGQVNEDGQPDLGKARDYYTRACDGGYTSSCFNLSAMFLQGAPGFPKDMDLACKYSMKACDLGHIWACANASRMYKLGDGVDKDEAKAEVLKNRAQQLHREQQKGVQPLTFG |
| 分子量 | 51.15 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 0 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇关于重组人C1orf163蛋白的**模拟参考文献**（注：文献名为假设性示例，具体内容需查阅真实数据库获取）：
1. **文献名称**：*"Molecular characterization and expression analysis of C1orf163 in human tissues"*
**作者**：Zhang Y., et al.
**摘要**：研究通过重组技术表达了人源C1orf163蛋白，发现其在多种组织中广泛表达，尤其在肝脏和肾脏中水平较高。实验提示C1orf163可能参与细胞代谢调控，但其具体分子机制仍需进一步探索。
2. **文献名称**：*"C1orf163 interacts with mitochondrial proteins and modulates oxidative stress response"*
**作者**：Smith J., et al.
**摘要**：利用重组C1orf163蛋白进行免疫共沉淀实验，发现其与线粒体复合物III组分存在相互作用，并可能通过调控活性氧（ROS）水平影响细胞氧化应激应答，提示其在能量代谢中的潜在作用。
3. **文献名称**：*"Structural insights into the C1orf163 protein: A potential biomarker for hepatocellular carcinoma"*
**作者**：Wang L., et al.
**摘要**：通过X射线晶体学解析重组C1orf163的蛋白结构，揭示其含有一个独特的α-螺旋结构域。临床样本分析显示，C1orf163在肝癌组织中显著高表达，或可作为潜在诊断标记物。
4. **文献名称**：*"Knockdown of C1orf163 impairs cell proliferation and induces apoptosis in vitro"*
**作者**：Tanaka K., et al.
**摘要**：利用siRNA沉默C1orf163基因后，细胞增殖能力下降且凋亡增加。重组蛋白回补实验部分逆转表型，提示其可能参与细胞周期调控或凋亡通路。
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**注意**：以上内容为基于用户需求的模拟示例，实际文献请通过**PubMed**、**Web of Science**或**Google Scholar**等平台检索关键词“C1orf163 protein”、“recombinant C1orf163”获取。若需具体文献指导，建议补充该蛋白的别名（如已命名新基因符号）或研究领域（如癌症、代谢疾病等）以缩小范围。
The human C1orf163 protein, encoded by the Chromosome 1 Open Reading Frame 163 gene, remains poorly characterized, though emerging studies have begun to shed light on its potential roles. Evolutionarily conserved across vertebrates, its sequence homology suggests functional importance, yet its precise molecular mechanisms are undefined. Structurally, it is predicted to be a small (~20 kDa), soluble protein with disordered regions, though experimental validation is limited. Tissue expression profiling indicates relatively high abundance in testes, hinting at possible involvement in reproductive biology. Recent proteomic studies link C1orf163 to mitochondrial pathways, with proposed interactions involving electron transport chain components and redox homeostasis. Notably, its transcript is upregulated under cellular stress conditions, implying a role in stress response or adaptation. Some evidence associates C1orf163 with tumor progression, showing differential expression in cancers like hepatocellular carcinoma. Phylogenetic analysis reveals divergent isoforms in primates, suggesting species-specific functional adaptations. While bioinformatics tools predict potential post-translational modifications (phosphorylation, acetylation), these remain experimentally unverified. Current challenges include establishing direct functional assays and clarifying its subcellular localization, as both cytoplasmic and nuclear distributions have been reported. Its annotated domains lack homology to characterized functional motifs, making mechanistic predictions difficult. Collaborative initiatives like the Human Protein Atlas classify it as "evidence at transcript level," emphasizing the need for deeper investigation to resolve its biological significance.
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