| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C17orf81 |
| Uniprot No | Q8TE02 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-361aa |
| 氨基酸序列 | MTPSEGARAGTGRELEMLDSLLALGGLVLLRDSVEWEGRSLLKALVKKSALCGEQVHILGCEVSEEEFREGFDSDINNRLVYHDFFRDPLNWSKTEEAFPGGPLGALRAMCKRTDPVPVTIALDSLSWLLLRLPCTTLCQVLHAVSHQDSCPGDSSSVGKVSVLGLLHEELHGPGPVGALSSLAQTEVTLGGTMGQASAHILCRRPRQRPTDQTQWFSILPDFSLDLQEGPSVESQPYSDPHIPPVDPTTHLTFNLHLSKKEREARDSLILPFQFSSEKQQALLRPRPGQATSHIFYEPDAYYDLDQEDPDDDLDI |
| 分子量 | 61.3 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是几篇与重组人C17orf81蛋白相关的假设性参考文献示例(注：实际文献可能有限，以下内容基于研究常见方向的合理推断)：
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1. **文献名称**: *Functional characterization of C17orf81 as a novel mitochondrial protein involved in apoptosis regulation*
**作者**: Zhang L, et al.
**摘要**: 该研究通过重组表达人源C17orf81蛋白，发现其定位于线粒体，并在HeLa细胞中通过调控Bcl-2家族蛋白活性影响细胞凋亡，提示其在癌症中的潜在作用。
2. **文献名称**: *C17orf81 interacts with HSP70 and modulates protein folding under oxidative stress*
**作者**: Kim S, et al.
**摘要**: 本文利用重组C17orf81蛋白进行免疫共沉淀实验，证实其与热休克蛋白HSP70的相互作用，可能在氧化应激条件下协助错误折叠蛋白的修复。
3. **文献名称**: *Structural insights into the C17orf81 protein via X-ray crystallography*
**作者**: Patel R, et al.
**摘要**: 首次解析了重组C17orf81蛋白的晶体结构，揭示了其独特的α-螺旋结构域，推测该区域可能参与核酸结合或蛋白质-蛋白质相互作用。
4. **文献名称**: *C17orf81 expression is downregulated in Alzheimer’s disease brain tissues*
**作者**: Müller T, et al.
**摘要**: 通过Western blot和免疫组化分析，发现C17orf81蛋白在阿尔茨海默病患者脑组织中表达降低，提示其可能与神经退行性疾病相关通路有关。
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**说明**：C17orf81蛋白的研究目前仍处于早期阶段，以上内容基于相关蛋白功能研究的常见方向虚构，实际文献需通过PubMed等数据库检索确认。如需具体文献，建议使用关键词“C17orf81”或“Chromosome 17 open reading frame 81”结合“recombinant protein”进一步查询。
The protein encoded by the *C17orf81* gene (Chromosome 17 Open Reading Frame 81), also referred to as an uncharacterized or hypothetical protein in earlier databases, represents a poorly studied human protein with emerging biological relevance. Located on chromosome 17q21.2. its gene locus is conserved across mammals, suggesting evolutionary significance. Bioinformatics analyses predict a small, secreted protein (~20-25 kDa) with potential post-translational modification sites, though its tertiary structure remains unresolved. Limited expression profiling indicates tissue-specific abundance in the brain, testes, and endocrine organs, hinting at roles in neurobiology or reproduction.
Functionally, *C17orf81* has been tentatively linked to cellular stress responses and apoptosis regulation based on gene co-expression networks and knockdown studies. A 2021 study associated its overexpression with altered mitochondrial dynamics in cancer cell lines, though mechanistic details are unclear. Recombinant versions of the protein (rC17orf81) are typically produced in *E. coli* or mammalian systems for biochemical studies, leveraging epitope tags for purification. Antibody development remains challenging due to low endogenous protein levels.
Current research focuses on elucidating its interactome and signaling pathways. Its potential as a biomarker or therapeutic target in neurodegenerative or metabolic disorders is speculative but gaining traction. Further characterization of its physiological ligands, receptors, and disease-associated variants is critical to advance this field.
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