Recombinant Human PVRL2 protein

中文名： 脊髓灰质炎病毒受体相关分子2(PVRL2)重组蛋白
别名： PVRL2；HVEB；PRR2；PVRL2；Nectin-2

货号: PA1000-7085

Price： ￥询价

20μg 50μg 100μg ＞100μg

数量：

大包装询价

产品详情

纯度	>90%SDS-PAGE.
种属	Human
靶点	PVRL2
Uniprot No	Q92692
内毒素	< 0.01EU/μg
表达宿主	E.coli
表达区间	32-360aa
氨基酸序列	QDVRVQVLPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPNTAGAGATGG
预测分子量	39.2kDa
蛋白标签	His tag N-Terminus
缓冲液	PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
稳定性 & 储存条件	Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
复溶	Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

参考文献

以下是关于PVRL2(Nectin-2)重组蛋白的3篇代表性文献摘要概述：

1. **文献名称**：*Structural characterization of recombinant PVRL2 and its interaction with viral ligands*

**作者**：Smith A, et al.

**摘要**：通过X射线晶体学解析了重组PVRL2胞外域的三维结构，揭示了其与疱疹病毒糖蛋白D的结合界面，为抗病毒药物设计提供了结构基础。

2. **文献名称**：*PVRL2-mediated cell adhesion in immune synapse formation*

**作者**：Chen L, et al.

**摘要**：研究证明重组PVRL2蛋白通过调节T细胞与抗原呈递细胞间的黏附，影响免疫突触稳定性，提示其在免疫治疗中的潜在应用价值。

3. **文献名称**：*Recombinant PVRL2-Fc fusion protein inhibits breast cancer metastasis in vivo*

**作者**：Wang Y, et al.

**摘要**：构建PVRL2-Fc重组融合蛋白，发现其通过阻断肿瘤细胞侵袭相关信号通路，在小鼠模型中显著抑制乳腺癌肺转移。

注：以上文献为示例性内容，实际研究中需通过PubMed/Google Scholar等平台检索真实文献。

背景信息

**Background of PVRL2 Recombinant Protein**

PVRL2 (Poliovirus Receptor-Related 2), also known as CD112 or NECTIN2. is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. It plays a critical role in cell adhesion, immune regulation, and viral entry. PVRL2 interacts with its ligands, including CD226 (DNAM-1) and TIGIT, to modulate immune synapse formation, particularly in T cells and natural killer (NK) cells, influencing anti-tumor and antiviral responses. Additionally, PVRL2 serves as an entry receptor for certain herpesviruses, such as herpes simplex virus (HSV), highlighting its dual role in immunity and pathogenesis.

Recombinant PVRL2 protein is engineered through molecular cloning, typically expressed in mammalian or insect cell systems to ensure proper post-translational modifications. This protein retains functional domains required for ligand binding and immune modulation, making it a valuable tool for studying receptor-ligand interactions, immune checkpoint pathways, and viral entry mechanisms. In research, it is employed to investigate mechanisms underlying autoimmune diseases, cancer immunotherapy (e.g., blocking PVRL2-TIGIT interactions to enhance immune activation), and antiviral strategies. Its structural and functional relevance also positions it as a potential therapeutic target or biomarker in diseases like melanoma and chronic infections.

Overall, PVRL2 recombinant protein bridges fundamental immunology and translational applications, offering insights into cell communication, immune evasion, and therapeutic intervention strategies.