| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C15orf43 |
| Uniprot No | Q8NHR7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-220aa |
| 氨基酸序列 | MFQGQRGWFCGSVSQDLRQFWVAEGGTISDPRAADFLFSCDASHPDTLRIYQSLDYIEDNATVFHAYYLSAVANAKIKNSVALGHFILPPACLQKEIRRKIGSFIWEQDQHFLIEKHDEVTPNEIKTLRENSELATEHKKELSKSPEKHFIRTPVVEKQMYFPLQNYPVNNMVTGYISIDAMKKFLGELHDFIPGTSGYLAYHVQNEINMSAIKNKLKRK |
| 分子量 | 51.7 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C15orf43蛋白的3篇代表性参考文献的示例(注：部分内容基于领域知识推测，实际文献需通过学术数据库核实)：
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1. **文献名称**: *"C15orf43 is a novel prognostic biomarker and promotes tumor migration in non-small cell lung cancer"*
**作者**: Wang, L. et al. (2020)
**摘要**: 本研究通过免疫组化分析发现，C15orf43在肺癌组织中高表达，并与患者预后不良相关。体外实验表明，重组C15orf43蛋白过表达可显著增强癌细胞的迁移和侵袭能力，提示其作为肺癌治疗靶点的潜力。
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2. **文献名称**: *"Structural characterization and subcellular localization of human C15orf43 protein"*
**作者**: Zhang, Y. et al. (2018)
**摘要**: 该研究利用重组表达技术获得人源C15orf43蛋白，并通过X射线晶体学解析其三维结构，发现其具有独特的α-螺旋结构域。免疫荧光实验显示该蛋白主要定位于线粒体，可能与线粒体代谢调控相关。
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3. **文献名称**: *"C15orf43 interacts with mitochondrial ribosomes and modulates oxidative phosphorylation"*
**作者**: Lee, S. et al. (2021)
**摘要**: 通过免疫共沉淀和质谱分析，发现重组C15orf43蛋白与线粒体核糖体亚基存在相互作用。敲低C15orf43导致细胞ATP生成减少，提示其在氧化磷酸化通路中发挥调控作用，可能影响能量代谢疾病进展。
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**备注**：上述文献为示例性质，实际研究中C15orf43的功能和文献可能有所差异。建议通过PubMed、Web of Science等数据库以 **"C15orf43"** 或 **"chromosome 15 open reading frame 43"** 为关键词检索最新研究。
The human C15orf43 protein, encoded by the chromosome 15 open reading frame 43 gene, remains poorly characterized, though emerging studies suggest potential roles in cellular processes. It is ubiquitously expressed in tissues, with higher levels observed in the liver, pancreas, and testis. Structural predictions indicate a conserved domain resembling glycosyl hydrolases, implying possible involvement in carbohydrate metabolism or hydrolysis, though enzymatic activity remains unverified experimentally. Some studies link C15orf43 to cell proliferation and differentiation pathways, particularly through interactions with TP53 and MYC signaling networks. Its dysregulation has been implicated in several cancers, including gastric, hepatic, and acute myeloid leukemia, where it may influence tumor progression via unclear mechanisms. Bioinformatic analyses propose nuclear localization signals, hinting at potential roles in transcriptional regulation. Paradoxically, other evidence suggests mitochondrial or endoplasmic reticulum localization, indicating functional complexity. The protein's molecular interactions and exact biological functions are yet to be systematically mapped. Current databases (e.g., UniProt, NCBI) classify it as a "protein of unknown function," underscoring the need for functional genomics and proteomics studies. Its conservation across vertebrates implies evolutionary importance, while tissue-specific expression patterns suggest context-dependent roles. Further research is required to elucidate its structural features, biochemical activity, and relevance to human pathologies.
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