| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C15orf38 |
| Uniprot No | Q7Z6K5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-226aa |
| 氨基酸序列 | MSRIYHDGAL RNKAVQSVRL PGAWDPAAHQ GGNGVLLEGE LIDVSRHSIL DTHGRKERYY VLYIRPSHIH RRKFDAKGNE IEPNFSATRK VNTGFLMSSY KVEAKGDTDR LTPEALKGLV NKPELLALTE SLTPDHTVAF WMPESEMEVM ELELGAGVRL KTRGDGPFLD SLAKLEAGTV TKCNFTGDGK TGASWTDNIM AQKCSKGAAA EIREQGDGAE DEEWDD |
| 分子量 | 51.3 KDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C15orf38蛋白的模拟参考文献，由于该蛋白的研究较为有限，以下内容基于合理推测归纳：
1. **文献名称**：*C15orf38 interacts with the transcription factor FOXM1 to promote cell proliferation in hepatocellular carcinoma*
**作者**：Chen L, Wang Y, et al.
**摘要**：研究发现C15orf38蛋白通过与FOXM1转录因子相互作用，增强其在肝癌细胞中的转录活性，促进细胞周期进程和肿瘤增殖。实验使用重组C15orf38蛋白验证了其直接结合FOXM1的机制。
2. **文献名称**：*Structural characterization of human C15orf38 reveals a potential role in mitochondrial metabolism*
**作者**：Zhang R, Liu X, et al.
**摘要**：通过重组表达并纯化人C15orf38蛋白，结合X射线晶体学解析其三维结构，发现其具有一个保守的底物结合口袋，暗示其可能参与线粒体相关代谢通路的调控。
3. **文献名称**：*C15orf38 is a novel binding partner of the BRCA1-BARD1 complex involved in DNA repair*
**作者**：Sato K, Nakamura S, et al.
**摘要**：质谱分析发现C15orf38与BRCA1-BARD1复合物相互作用，并通过重组蛋白实验证实其结合依赖BRCA1的RING结构域。敲低C15orf38导致DNA损伤修复效率下降，提示其在基因组稳定性中的作用。
4. **文献名称**：*Expression profiling and functional analysis of C15orf38 in inflammatory bowel disease*
**作者**：Müller T, Schmidt C, et al.
**摘要**：研究报道C15orf38在炎症性肠病患者肠道组织中高表达，重组蛋白体外实验显示其能激活NF-κB信号通路，促进巨噬细胞释放炎性因子，可能参与疾病进展。
---
注：以上文献为模拟示例，实际研究中可能需结合具体数据库(如PubMed、UniProt)验证。建议通过关键词“C15orf38 recombinant protein”或“C15orf38 function”进一步检索。
Here’s a concise yet informative description of recombinant human C15orf38 protein:
Recombinant human C15orf38 (chromosome 15 open reading frame 38) is a protein encoded by the *C15orf38* gene, located on chromosome 15q21.2. Though its biological functions remain partially characterized, studies suggest its involvement in cellular processes such as protein-protein interactions and potential roles in reproductive biology. The protein is predicted to contain conserved structural domains, including a signal peptide indicative of secretory function, and may participate in extracellular signaling pathways. Research has linked C15orf38 expression to spermatogenesis, with elevated levels observed in testicular tissues, implying a role in male fertility. Recent investigations also explore its potential association with cancer progression, as altered expression patterns have been detected in certain tumors. Recombinant forms of C15orf38 are typically produced using expression systems like *E. coli* or mammalian cells for functional studies, enabling exploration of its molecular mechanisms. Despite advances, the protein's exact physiological role, post-translational modifications, and clinical relevance require further elucidation, making it a subject of growing interest in both basic and translational research contexts.
×
