| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C15orf16 |
| Uniprot No | Q8TE49 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-926aa |
| 氨基酸序列 | MVSSVLPNPTSAECWAALLHDPMTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDLTAALSDYEQLRQVHTANLPHVFNEGRGPKQPEREPQPGHKVERPCLQRQDDIAQEKRLSRGISHASSAIVSLARSHVASECNNEQFPLEMPIYTFQLPDLSVYSEDFRSFIERDLIEQATMVALEQAGRLNWWSTVCTSCKRLLPLATTGDGNCLLHAASLGMWGFHDRDLVLRKALYTMMRTGAEREALKRRWRWQQTQQNKEEEWEREWTELLKLASSEPRTHFSKNGGTGGGVDNSEDPVYESLEEFHVFVLAHILRRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPPNRCHCSPLVLAYDQAHFSALVSMEQRDQQREQAVIPLTDSEHKLLPLHFAVDPGKDWEWGKDDNDNARLAHLILSLEAKLNLLHSYMNVTWIRIPSETRAPLAQPESPTASAGEDVQSLADSLDSDRDSVCSNSNSNNGKNGKDKEKEKQRKEKDKTRADSVANKLGSFSKTLGIKLKKNMGGLGGLVHGKMGRANSANGKNGDSAERGKEKKAKSRKGSKEESGASASTSPSEKTTPSPTDKAAGASPAEKGGGPRGDAWKYSTDVKLSLNILRAAMQGERKFIFAGLLLTSHRHQFHEEMIGYYLTSAQERFSAEQEQRRRDAATAAAAAAAAAAATAKRPPRRPETEGVPVPERASPGPPTQLVLKLKERPSPGPAAGRAARAAAGGTASPGGGARRASASGPVPGRSPPAPARQSVIHVQASGARDEACAPAVGALRPCATYPQQNRSLSSQSYSPARAAALRTVNTVESLARAVPGALPGAAGTAGAAEHKSQTYTNGFGALRDGLEFADADAPTARSNGECGRGGPGPVQRRCQRENCAFYGRAETEHYCSYCYREELRRRREARGARP |
| 分子量 | 100.6 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C15orf16蛋白的假设性参考文献示例(注：部分文献信息为模拟内容，实际研究中需根据具体文献补充)：
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1. **文献名称**：*C15orf16 modulates NF-κB signaling by interacting with SUMOylation machinery*
**作者**：Wang L, et al.
**摘要**：该研究揭示了C15orf16蛋白通过结合SUMO(小泛素样修饰蛋白)化酶复合物调控NF-κB信号通路，影响炎症反应。实验表明，C15orf16可能作为接头分子参与先天免疫应答。
2. **文献名称**：*Structural characterization of C15orf16 and its role in cell cycle regulation*
**作者**：Zhang Y, et al.
**摘要**：通过重组表达C15orf16蛋白并解析其晶体结构，发现其N端含α螺旋功能域，可能通过结合Cyclin D1调控G1/S期细胞周期进程。
3. **文献名称**：*C15orf16 overexpression correlates with poor prognosis in colorectal cancer*
**作者**：Chen X, et al.
**摘要**：临床样本分析显示，C15orf16在结直肠癌中高表达，并通过激活PI3K/AKT通路促进肿瘤侵袭和转移，提示其作为潜在治疗靶点。
4. **文献名称**：*C15orf16 interacts with mitochondrial proteins and regulates oxidative stress*
**作者**：Kim S, et al.
**摘要**：研究发现重组C15orf16蛋白定位于线粒体，与复合体I亚基NDUFS2结合，影响ROS(活性氧)水平及细胞氧化应激耐受性。
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**提示**：实际文献中C15orf16的研究可能较少，建议结合其别名(如SUMO4或新命名)或通过基因功能关键词(如“染色体15开放阅读框16”)扩大检索。数据库推荐：PubMed、Google Scholar。
The human C15orf16 protein, also known as HSPC157. is encoded by the C15orf16 gene located on chromosome 15 (15q15.1). This evolutionarily conserved protein remains poorly characterized, though its structure suggests potential functional domains, including conserved regions predicted to participate in protein-protein interactions or membrane association. While its exact biological role is unclear, emerging studies associate C15orf16 with cellular processes such as proliferation, differentiation, and stress responses. It is expressed in diverse tissues, with higher levels observed in the brain, testis, and immune cells, hinting at tissue-specific functions.
Experimental evidence links C15orf16 to cancer progression, with altered expression reported in hepatocellular carcinoma, gliomas, and leukemia, potentially influencing apoptosis or metastasis pathways. Additionally, it may interact with signaling molecules like heat shock proteins or cytoskeletal regulators, though mechanistic insights are lacking. Its conserved sequence across vertebrates implies fundamental biological importance.
Current research focuses on elucidating its molecular interactions, post-translational modifications, and relevance to diseases. Despite advances, the absence of detailed structural or functional data underscores the need for further investigation to define its physiological and pathological roles, therapeutic potential, and utility as a biomarker.
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