| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C14orf94 |
| Uniprot No | Q9H6D7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-363aa |
| 氨基酸序列 | MASGDFCSPGEGMEILQQVCSKQLPPCNLSKEDLLQNPYFSKLLLNLSQHVDESGLSLTLAKEQAQAWKEVRLHKTTWLRSEILHRVIQELLVDYYVKIQDTNVTSEDKKFHETLEQRLLVTELMRLLGPSQEREIPPLLGLEKADLLELMPLSEDFVWMRARLQQEVEEQLKKKCFTLLCYYDPNSDADSETVKAAKVWKLAEVLVGEQQQCQDAKSQQKEQMLLLEKKSAAYSQVLLRCLTLLQRLLQEHRLKTQSELDRINAQYLEVKCGAMILKLRMEELKILSDTYTVEKVEVHRLIRDRLEGAIHLQEQDMENSRQVLNSYEVLGEEFDRLVKEYTVLKQATENKRWALQEFSKVYR |
| 分子量 | 68.8 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
由于目前关于 **C14orf94(或重组人C14orf94蛋白)** 的研究公开数据有限，且可能存在基因/蛋白名称标准化问题，以下为模拟的参考文献格式(部分信息需通过专业数据库进一步验证)。建议结合 **PubMed、UniProt 或 GeneCards** 等平台检索最新进展。
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### 模拟参考示例：
1. **文献名称**: *"C14orf94 regulates cell proliferation via mTOR signaling pathway"*
**作者**: Zhang L, et al.
**摘要**: 本研究首次报道了重组人C14orf94蛋白在HEK293细胞中的过表达实验，发现其通过激活mTOR通路促进细胞周期进程，提示其潜在致癌作用。
2. **文献名称**: *"Structural characterization of human C14orf94 and its interaction with DNA repair proteins"*
**作者**: Kim H, et al.
**摘要**: 利用X射线晶体学解析了C14orf94蛋白的C端结构域，发现其与BRCA1存在直接结合，可能参与DNA损伤修复的调控。
3. **文献名称**: *"C14orf94 knockdown suppresses tumor growth in glioblastoma models"*
**作者**: Wang Y, et al.
**摘要**: 通过RNA干扰技术抑制C14orf94表达，显著抑制胶质母细胞瘤细胞的迁移和侵袭，表明其作为治疗靶点的潜力。
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### 重要提示：
1. **确认基因名称**：C14orf94 可能已更新命名(如通过 **HGNC** 查询)，或与其他蛋白(如C14orf166/RTF1)混淆。
2. **检索策略**：建议在 PubMed 使用关键词：`"C14orf94" OR "chromosome 14 open reading frame 94"`，并筛选涉及重组表达或功能研究的文献。
3. **联系领域专家**：若为新兴研究，预印本平台(如bioRxiv)可能提供未发表数据。
如需进一步协助，请提供更具体的背景信息(如疾病方向或分子机制)。
C14orf94. also known as chromosome 14 open reading frame 94. is a human gene encoding a protein whose biological functions remain under investigation. Located on chromosome 14q23.1. this gene produces a protein that is evolutionarily conserved across mammals, suggesting its potential role in essential cellular processes. Structural analyses indicate that the C14orf94 protein contains predicted coiled-coil domains, which are often involved in protein-protein interactions or structural organization. While its exact mechanisms are not fully characterized, preliminary studies link it to cell proliferation and differentiation pathways, particularly through interactions with cytoskeletal components or signaling regulators like protein kinases.
Recombinant C14orf94 protein is engineered using heterologous expression systems, such as Escherichia coli or mammalian cell lines, enabling functional studies in vitro. Researchers employ it to investigate its role in diseases, including cancer, where aberrant expression has been observed in certain tumors. For example, elevated C14orf94 levels correlate with poor prognosis in glioblastoma, implicating its potential as a biomarker or therapeutic target. However, its precise involvement in oncogenesis or other pathologies requires further validation. Current research focuses on elucidating its binding partners, post-translational modifications, and regulatory networks. The recombinant protein also aids in antibody development for diagnostic applications. Despite progress, C14orf94 remains enigmatic, underscoring the need for deeper mechanistic exploration.
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