| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C14orf24 |
| Uniprot No | Q8N128 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-213 aa |
| 氨基酸序列 | MDQEPVGGVERGEAVAASGAAAAAAFGESAGQMSNERGFENVELGVIGKKKKVPRRVIHFVSGETMEEYSTDEDEVDGLEKKDVLPTVDPTKLTWGPYLWFYMLRAATSTLSVCDFLGEKIASVLGISTPKYQYAIDEYYRMKKEEEEEEEENRMSEEAEKQYQQNKLQTDSIVQTDQPETVISSSFVNVNFEMEGDSEVIMESKQNPVSVPP |
| 分子量 | 50.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为3条关于重组人C14orf24蛋白的虚构参考文献示例(内容基于公开知识框架生成，非真实文献)：
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1. **文献名称**：*"Molecular Cloning and Characterization of Human C14orf24 as a Novel Mitochondrial Protein Involved in Apoptosis Regulation"*
**作者**：Li X. et al.
**摘要**：研究首次克隆了C14orf24基因，并通过重组蛋白表达验证其定位于线粒体。实验表明过表达C14orf24可抑制HeLa细胞凋亡，提示其在细胞死亡调控中的潜在作用。
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2. **文献名称**：*"C14orf24 Interacts with mTOR Signaling Pathway to Modulate Cellular Autophagy"*
**作者**：Zhang Y. et al.
**摘要**：通过免疫共沉淀发现C14orf24与mTOR复合物存在物理互作。重组C14orf24蛋白体外实验证实其能增强mTOR活性，进而抑制自噬，提示其作为癌症治疗的潜在靶点。
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3. **文献名称**：*"Structural Analysis of Recombinant C14orf24 Reveals a Conserved Alpha-Helical Domain Critical for DNA Binding"*
**作者**：Wang Q. et al.
**摘要**：利用X射线晶体学解析重组C14orf24蛋白的三维结构，发现其含有一个新型α螺旋结构域，并通过电泳迁移实验(EMSA)证明该区域介导DNA结合功能，可能参与基因组稳定性维持。
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注：以上文献为模拟生成，实际研究请通过PubMed/Google Scholar检索真实文献。
C14orf24 (also known as chromosome 14 open reading frame 24) is a protein encoded by the C14orf24 gene located on human chromosome 14q22.1. Its biological role remains incompletely understood, but emerging studies suggest potential involvement in cellular processes such as proliferation, apoptosis, and cancer progression. The protein contains a nuclear localization signal and is predominantly localized in the nucleus, hinting at possible regulatory functions in gene expression or DNA damage response. Structurally, it is characterized by a conserved N-terminal domain and a C-terminal region rich in proline residues, which may mediate protein-protein interactions.
Research has linked C14orf24 to tumorigenesis, with elevated expression observed in several cancers, including hepatocellular carcinoma, breast cancer, and colorectal cancer. It may interact with p53. potentially modulating tumor suppressor pathways. Recombinant human C14orf24 protein (produced via heterologous expression systems like *E. coli* or mammalian cells) facilitates functional studies, aiding in deciphering its molecular mechanisms. Despite progress, its precise physiological and pathological roles, post-translational modifications, and interacting partners remain under investigation. Current efforts focus on validating its utility as a diagnostic biomarker or therapeutic target in oncology. Further mechanistic insights could enhance understanding of its dual roles in cellular homeostasis and disease contexts.
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