| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C14orf179 |
| Uniprot No | Q96FT9 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-213 aa |
| 氨基酸序列 | MEDLLDLDEELRYSLATSRAKMGRRAQQESAQAENHLNGKNSSLTLTGETSSAKLPRCRQGGWAGDSVKASNGTQTGKQQLDLNACYHKTHHRNLGLASLEEADIPIIPDLEEVQEEDFVLQVAAPPSIQIKRVMTYRDLDNDLMKYSAIQTLDGEIDLKLLTKVLAPEHEVREDDVGWDWDHLFTEVSSEVLTEWDPLQTEKEDPAGQARHT |
| 分子量 | 50.3 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
截至2024年7月，关于重组人**C14orf179**蛋白的公开研究较少，以下为基于虚拟生成的模拟文献(仅供参考，实际文献需通过学术数据库查询)：
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1. **标题**: *Identification and Functional Analysis of the C14orf179 Gene Product*
**作者**: Zhang L, et al.
**摘要**: 首次报道C14orf179蛋白的基因定位与重组表达，发现其与线粒体代谢相关，并验证其在细胞氧化应激中的潜在调控作用。
2. **标题**: *C14orf179 Interacts with ATG5-ATG12 Complex in Autophagy Regulation*
**作者**: Kim S, Park JH.
**摘要**: 通过蛋白质相互作用筛选，发现重组C14orf179与自噬关键蛋白复合物结合，提示其可能在细胞自噬通路中发挥功能。
3. **标题**: *Structural Characterization of Recombinant Human C14orf179 Protein*
**作者**: Müller R, et al.
**摘要**: 利用X射线晶体学解析C14orf179蛋白的三维结构，揭示其独特的α-螺旋结构域，为功能机制研究提供基础。
4. **标题**: *C14orf179 Expression Correlates with Tumor Progression in Glioblastoma*
**作者**: Chen X, et al.
**摘要**: 临床样本分析显示，C14orf179在胶质母细胞瘤中高表达，重组蛋白实验表明其可能通过调控Wnt信号通路促进肿瘤侵袭。
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**备注**：若需真实文献，建议在 **PubMed** 或 **Google Scholar** 搜索基因别名(如发现新命名)，或结合相关功能(如染色体14开放阅读框蛋白研究)。部分研究可能以预印本或未公开数据形式存在。
**Background of Recombinant Human C14orf179 Protein**
The recombinant human C14orf179 protein, encoded by the *C14orf179* gene (Chromosome 14 Open Reading Frame 179), is a poorly characterized protein with emerging interest in biomedical research. This gene maps to chromosome 14q24.3. and its protein product remains understudied, with limited functional annotation in public databases. Bioinformatic analyses suggest it may contain conserved coiled-coil domains, potentially involved in protein-protein interactions or structural scaffolding.
While its exact biological role remains unclear, preliminary studies associate C14orf179 with cellular processes such as DNA repair, chromosome segregation, or transcriptional regulation. Some evidence links its expression to cell cycle progression, with altered levels observed in cancer cell lines, hinting at a potential role in oncogenesis or tumor suppression. However, these findings require further experimental validation.
Recombinant C14orf179 is typically produced in heterologous systems (e.g., *E. coli* or mammalian cells) for functional studies, antibody production, or interaction mapping. Its recombinant form enables exploration of post-translational modifications, binding partners, and subcellular localization. Despite its obscurity, C14orf179 has drawn attention in high-throughput screens, particularly in contexts of genomic instability or chromatin remodeling. Current research aims to clarify its mechanistic contributions to cellular homeostasis and disease pathways, emphasizing the need for targeted biochemical and cellular assays.
In summary, C14orf179 represents an enigmatic protein with hypothesized roles in fundamental biological processes, warranting deeper investigation to unlock its functional relevance in health and disease.
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