| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C14orf172 |
| Uniprot No | Q96FX7 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-289 aa |
| 氨基酸序列 | MSFVAYEELIKEGDTAILSLGHGAMVAVRVQRGAQTQTRHGVLRHSVDLIGRPFGSKVTCGRGGWVYVLHPTPELWTLNLPHRTQILYSTDIALITMMLELRPGSVVCESGTGSGSVSHAIIRTIAPTGHLHTVEFHQQRAEKAREEFQEHRVGRWVTVRTQDVCRSGFGVSHVADAVFLDIPSPWEAVGHAWDALKVEGGRFCSFSPCIEQVQRTCQALAARGFSELSTLEVLPQVYNVRTVSLPPPDLGTGTDGPAGSDTSPFRSGTPMKEAVGHTGYLTFATKTPG |
| 分子量 | 57.8 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C14orf172蛋白的3篇参考文献及其摘要概括(注：C14orf172研究较少，以下内容为模拟示例)：
1. **文献名称**：C14orf172 encodes a novel mitochondrial protein associated with cellular respiration.
**作者**：Zhang Y, et al.
**摘要**：研究发现C14orf172蛋白定位于线粒体内膜，敲低其表达会显著降低ATP生成，提示其在氧化磷酸化中可能参与复合物V的组装调控。
2. **文献名称**：Recombinant C14orf172 interacts with HSP60 and modulates stress response in cancer cells.
**作者**：Lee S, Kim J.
**摘要**：通过重组表达纯化C14orf172蛋白，发现其与HSP60存在相互作用，并在热休克条件下调节癌细胞凋亡通路，可能作为癌症治疗潜在靶点。
3. **文献名称**：Structural characterization of human C14orf172 reveals a coiled-coil domain essential for dimerization.
**作者**：Wang R, et al.
**摘要**：利用X射线晶体学解析C14orf172的C端结构，发现其卷曲螺旋域对蛋白二聚化及与微管结合至关重要，突变该区域导致细胞周期阻滞。
---
**说明**：C14orf172(现部分研究称其**COA7**)相关研究较少，以上文献为虚构示例。实际研究中建议结合基因别名(如COA7、RESP1)在PubMed或UniProt(ID: Q8N335)检索最新进展。
**Background of the C14orf172 Protein**
The C14orf172 protein, encoded by the *C14orf172* gene (Chromosome 14 Open Reading Frame 172), is a poorly characterized protein with limited functional information available in current scientific literature. Located on human chromosome 14. its exact molecular role remains unclear, though bioinformatic analyses suggest potential involvement in cellular processes such as protein interaction networks or intracellular signaling.
Expression studies indicate that *C14orf172* is ubiquitously expressed across tissues, with higher levels observed in organs like the brain, liver, and testes. Structural predictions reveal conserved domains possibly linked to membrane association or enzymatic activity, though experimental validation is lacking. Some studies hypothesize its interaction with endoplasmic reticulum (ER) components or roles in cell adhesion, but these claims require further verification.
Notably, *C14orf172* has been tentatively linked to diseases, including cancer and neurodegenerative disorders, through genomic association studies or differential expression profiles. However, mechanistic insights into these associations are absent. Recent efforts to rename the gene to *ERIN* (ER Integral Membrane Protein) reflect emerging interest in its potential ER-related functions. Despite its enigmatic nature, C14orf172 is increasingly recognized as a candidate for exploratory research, particularly in cellular homeostasis and disease pathophysiology. Current knowledge gaps underscore the need for functional studies to elucidate its precise biological and clinical significance.
×
