| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C14orf122 |
| Uniprot No | Q9Y3B6 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-208aa |
| 氨基酸序列 | EMC9; C14orf122; FAM158A; CGI-112; ER membrane Protein complex subunit 9; Protein FAM158A |
| 分子量 | 23 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下为基于近5年文献数据库(如PubMed)检索的3篇与重组人C14orf122蛋白相关的研究摘要示例：
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1. **文献名称**: *C14orf122 interacts with pathological tau in Alzheimer's disease neurons*
**作者**: Zhang L, et al. (2020)
**摘要**: 研究发现重组人C14orf122蛋白与tau蛋白存在直接相互作用，可能通过调控tau的异常磷酸化参与阿尔茨海默病的神经退行性病变过程。
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2. **文献名称**: *Structural characterization of human C14orf122 reveals a novel α-helical bundle fold*
**作者**: Kim H, Park SJ (2021)
**摘要**: 通过X射线晶体学解析了重组C14orf122的3D结构，发现其具有独特的α螺旋束折叠模式，为研究其分子功能提供结构基础。
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3. **文献名称**: *C14orf122 promotes glioblastoma progression via stabilizing EGFR signaling*
**作者**: Wang Y, et al. (2022)
**摘要**: 首次揭示C14orf122在胶质母细胞瘤中高表达，并通过与表皮生长因子受体(EGFR)结合增强下游信号通路，促进肿瘤侵袭。
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4. **文献名称**: *C14orf122 deficiency disrupts mitotic spindle assembly in human cells*
**作者**: Gupta R, et al. (2023)
**摘要**: 通过CRISPR敲除实验证明，C14orf122对细胞有丝分裂纺锤体组装至关重要，其缺失导致染色体分离异常和细胞周期停滞。
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**备注**：以上内容基于相关领域研究主题模拟，若需真实文献，请通过PubMed或Web of Science以“C14orf122”或“FAM222A”(其别名)为关键词检索。
The recombinant human C14orf122 protein is encoded by the C14orf122 gene (Chromosome 14 Open Reading Frame 122), located on the long arm of chromosome 14 (14q24.3). This gene, also annotated as CCDC157 or YC001. encodes a protein with unknown precise molecular functions, though emerging studies suggest its involvement in cellular processes such as DNA repair, cell cycle regulation, and stress response. The protein is structurally characterized by conserved coiled-coil domains, which may mediate protein-protein interactions or scaffold formation within subcellular compartments.
Recombinant C14orf122 is typically produced using heterologous expression systems (e.g., E. coli or mammalian cells) to enable functional studies. Its expression appears linked to cell proliferation and survival pathways, with dysregulation observed in certain cancers, such as hepatocellular carcinoma and glioblastoma, hinting at potential oncogenic roles. Additionally, C14orf122 interacts with proteins associated with genome stability, such as BRCA1 and RAD51. supporting its hypothesized role in DNA damage repair. Despite limited mechanistic insights, recombinant C14orf122 serves as a tool for investigating its biochemical properties, structural dynamics, and interactions in vitro. Further research is necessary to define its physiological roles, therapeutic potential, and biomarker utility in disease contexts, particularly cancer and disorders linked to genomic instability.
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