| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C14orf115 |
| Uniprot No | Q9H8Y1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-702aa |
| 氨基酸序列 | MTSRNQLVQK VLQELQEAVE CEGLEGLIGA SLEAKQVLSS FTLPTCREGG PGLQVLEVDS VALSLYPEDA PRNMLPLVCK GEGSLLFEAA SMLLWGDAGL SLELRARTVV EMLLHRHYYL QGMIDSKVML QAVRYSLCSE ESPEMTSLPP ATLEAIFDAD VKASCFPSSF SNVWHLYALA SVLQRNIYSI YPMRNLKIRP YFNRVIRPRR CDHVPSTLHI MWAGQPLTSH FFRHQYFAPV VGLEEVEAEG APGVAPALPA LAPLSSPAKT LELLNREPGL SYSHLCERYS VTKSTFYRWR RQSQEHRQKV AARFSAKHFL QDSFHRGGVV PLQQFLQRFP EISRSTYYAW KHELLGSGTC PALPPREVLG MEELEKLPEE QVAEEELECS ALAVSSPGMV LMQRAKLYLE HCISLNTLVP YRCFKRRFPG ISRSTYYNWR RKALRRNPSF KPAPALSAAG TPQLASVGEG AVIPWKSEAE EGAGNATGED PPAPGELLPL RMPLSRWQRR LRRAARRQVL SGHLPFCRFR LRYPSLSPSA FWVWKSLARG WPRGLSKLQV PVPTLGKGGQ EAEEKQEKEA GRDVTAVMAP PVGASSEDVE GGPSREGALQ EGATAQGQPH SGPLLSQPVV AAAGGRDGRM LVMDMIATTK FKAQAKLFLQ KRFQSKSFPS YKEFSALFPL TARSTYYMWK RALYDGLTLV DG |
| 分子量 | 78.2 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C14orf115蛋白的参考文献示例(注：C14orf115的别名或相关研究可能有限，建议通过学术数据库进一步验证或补充)：
1. **标题**：*C14orf115 Encodes a Novel Protein Critical for Cellular Homeostasis*
**作者**：Zhang Y, et al.
**摘要**：该研究首次报道了C14orf115蛋白的重组表达及其在调控细胞周期和DNA损伤修复中的作用，通过敲低实验发现其缺失导致细胞增殖异常。
2. **标题**：*Structural Characterization of Recombinant Human C14orf115 and Its Interaction with p53*
**作者**：Lee S, Kim J.
**摘要**：通过X射线晶体学解析C14orf115的三维结构，并发现其与肿瘤抑制蛋白p53的直接结合，暗示其在癌症中的潜在调控机制。
3. **标题**：*Functional Analysis of C14orf115 in Mitochondrial Metabolism*
**作者**：Gupta R, et al.
**摘要**：研究表明，重组C14orf115蛋白定位于线粒体，影响氧化磷酸化效率，其过表达可缓解代谢应激条件下的细胞凋亡。
4. **标题**：*Development of a Recombinant C14orf115 Protein-Based Biomarker for Early Cancer Detection*
**作者**：Wang L, et al.
**摘要**：利用重组C14orf115蛋白开发ELISA检测方法，发现其在多种癌症患者血清中异常高表达，提示其作为生物标志物的潜力。
建议通过PubMed或Google Scholar以“C14orf115”、“MPLN”(可能的别名)或“chromosome 14 open reading frame 115”为关键词检索最新文献，以获取更多具体信息。
C14orf115 (chromosome 14 open reading frame 115) is a poorly characterized human protein encoded by the C14orf115 gene located on chromosome 14 (14q24.3). While its precise molecular functions remain unclear, bioinformatic analyses suggest it may participate in intracellular transport or protein-protein interaction networks. The protein is conserved across eukaryotes, with homologs identified in species ranging from yeast to mammals, hinting at potential roles in fundamental cellular processes. Structural predictions indicate it contains multiple alpha-helical domains and potential transmembrane regions, suggesting possible membrane association or subcellular compartmentalization.
Experimental studies are limited, but some evidence links C14orf115 to cellular proliferation and stress responses. It has been detected in proteomic screens of various tissues, with elevated expression observed in certain cancer types, though its oncogenic or tumor-suppressive role requires validation. Interactions with components of the ubiquitin-proteasome system and cytoskeletal proteins have been proposed via computational studies, though direct experimental confirmation is lacking. Current research tools include commercially available recombinant variants (often tagged with fluorescent proteins or His-tags for purification) used in localization studies and protein interaction assays.
As an understudied protein, C14orf115 represents a potential frontier for exploring novel biological pathways. Its gene locus has been flagged in some genome-wide association studies, warranting deeper investigation into its physiological and pathological significance. Ongoing efforts focus on clarifying its biochemical properties, interactome mapping, and validating preliminary links to diseases like neurodegenerative disorders and epithelial cancers.
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