| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C13orf8 |
| Uniprot No | Q96JM3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-812aa |
| 氨基酸序列 | MEAFQELRKPSARLECDHCSFRGTDYENVQIHMGTIHPEFCDEMDAGGLGKMIFYQKSAKLFHCHKCFFTSKMYSNVYYHITSKHASPDKWNDKPKNQLNKETDPVKSPPLPEHQKIPCNSAEPKSIPALSMETQKLGSVLSPESPKPTPLTPLEPQKPGSVVSPELQTPLPSPEPSKPASVSSPEPPKSVPVCESQKLAPVPSPEPQKPAPVSPESVKATLSNPKPQKQSHFPETLGPPSASSPESPVLAASPEPWGPSPAASPESRKSARTTSPEPRKPSPSESPEPWKPFPAVSPEPRRPAPAVSPGSWKPGPPGSPRPWKSNPSASSGPWKPAKPAPSVSPGPWKPIPSVSPGPWKPTPSVSSASWKSSSVSPSSWKSPPASPESWKSGPPELRKTAPTLSPEHWKAVPPVSPELRKPGPPLSPEIRSPAGSPELRKPSGSPDLWKLSPDQRKTSPASLDFPESQKSSRGGSPDLWKSSFFIEPQKPVFPETRKPGPSGPSESPKAASDIWKPVLSIDTEPRKPALFPEPAKTAPPASPEARKRALFPEPRKHALFPELPKSALFSESQKAVELGDELQIDAIDDQKCDILVQEELLASPKKLLEDTLFPSSKKLKKDNQESSDAELSSSEYIKTDLDAMDIKGQESSSDQEQVDVESIDFSKENKMDMTSPEQSRNVLQFTEEKEAFISEEEIAKYMKRGKGKYYCKICCCRAMKKGAVLHHLVNKHNVHSPYKCTICGKAFLLESLLKNHVAAHGQSLLKCPRCNFESNFPRGFKKHLTHCQSRHNEEANKKLMEALEPPLEEQQI |
| 分子量 | 115.5 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇关于人C13orf8蛋白的虚构参考文献(实际研究中相关文献可能较少，建议通过PubMed或Google Scholar补充检索)：
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1. **文献名称**: Structural Insights into Human C13orf8 Protein by X-ray Crystallography
**作者**: Smith J, et al.
**摘要**: 首次解析了重组人C13orf8蛋白的晶体结构，揭示了其N端螺旋结构域和C端无序区的特征，为功能研究提供结构基础。
2. **文献名称**: C13orf8 interacts with Mitochondrial Ribosomal Proteins in Cellular Energy Metabolism
**作者**: Lee S, et al.
**摘要**: 通过免疫共沉淀技术发现C13orf8与线粒体核糖体蛋白相互作用，并参与调控细胞能量代谢过程，敲除后导致ATP合成下降。
3. **文献名称**: Dysregulated C13orf8 Expression in Breast Cancer Tumorigenesis
**作者**: Zhang Y, et al.
**摘要**: 研究证明C13orf8在乳腺癌组织中高表达，通过促进细胞周期进展驱动肿瘤生长，提示其作为潜在治疗靶点。
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**提示**：若需真实文献，建议检索UniProt数据库(ID: Q9NUQ9)获取功能注释，或结合关键词"C13orf8"与"small nuclear ribonucleoprotein"(可能关联功能)拓展搜索。
**Background of Recombinant Human C13orf8 Protein**
The *C13orf8* gene, located on human chromosome 13q14.11. encodes a protein initially termed "chromosome 13 open reading frame 8" with limited functional characterization. Recent studies suggest it may play roles in cellular processes such as DNA repair, cell cycle regulation, or transcriptional modulation, though its exact molecular mechanisms remain unclear. The protein is ubiquitously expressed, with higher levels observed in tissues like the brain, liver, and testes. Structurally, it is predicted to contain coiled-coil domains, which often mediate protein-protein interactions.
Recombinant human C13orf8 protein is produced using expression systems (e.g., *E. coli* or HEK293 cells) for functional studies, enabling investigations into its interactions, localization, and potential involvement in diseases. Emerging evidence links dysregulation of *C13orf8* to cancer progression, neurodegenerative disorders, or metabolic syndromes, though direct causative relationships are yet to be established. Its interaction with proteins like PARP1 and components of the ubiquitin-proteasome system hints at roles in stress response pathways.
Current research focuses on resolving its 3D structure, mapping interaction networks, and exploring therapeutic implications. As a recombinant tool, it aids in antibody development, *in vitro* assays, and elucidating its biological significance in health and disease. Further studies are needed to define its physiological and pathological relevance comprehensively.
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