关键信息
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基因名
ORNT1
- 应用
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别名
ORNT1；ORC1；ORNT1；Mitochondrial ornithine transporter 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y619
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表达区间
1-301aa
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氨基酸序列
MKSNPAIQAAIDLTAGAAGGTACVLTGQPFDTMKVKMQTFPDLYRGLTDCCLKTYSQVGFRGFYKGTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALVLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLREVPGYFFFFGGYELSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAVYPVDCIKSRIQVLSMSGKQAGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYEYSRKLMMNQLEAY
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分子量
59.7kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
ORNT1, or Oxidized Reduced Nicotinamide Adenine Dinucleotide Transporter 1, is a mitochondrial transporter that plays a crucial role in cellular metabolism. It is implicated in the transport of oxidized NAD and serves as a key component in maintaining the balance of NAD+/NADH ratios in mitochondria, which is essential for various metabolic processes, including energy production and apoptosis. Research has shown that ORNT1 is involved in the regulation of cellular redox states and may influence the pathophysiology of various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. The interest in ORNT1 recombinant protein arises from its potential as a therapeutic target, as well as its utility in understanding mitochondrial dysfunction. Studies have focused on the characterization of ORNT1's structural properties and functional mechanisms, using recombinant protein expression techniques to produce ORNT1 in heterologous systems. Investigating ORNT1 can provide valuable insights into mitochondrial dynamics and its implications for human health, paving the way for novel therapeutic interventions aimed at restoring mitochondrial function and metabolic homeostasis.
