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| 纯度 | >95%SDS-PAGE. |
| 种属 | Human |
| 靶点 | CD5L |
| Uniprot No | O43866 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 20-347aa |
| 氨基酸序列 | MKHHHHHHASPSGVRLVGGLHRCEGRVEVEQKGQWGTVCDDGWDIKDVAV LCRELGCGAASGTPSGILYEPPAEKEQKVLIQSVSCTGTEDTLAQCEQEE VYDCSHDEDAGASCENPESSFSPVPEGVRLADGPGHCKGRVEVKHQNQWY TVCQTGWSLRAAKVVCRQLGCGRAVLTQKRCNKHAYGRKPIWLSQMSCSG REATLQDCPSGPWGKNTCNHDEDTWVECEDPFDLRLVGGDNLCSGRLEVL HKGVWGSVCDDNWGEKEDQVVCKQLGCGKSLSPSFRDRKCYGPGVGRIWL DNVRCSGEEQSLEQCQHRFWGFHDCTHQEDVAVICSG |
| 预测分子量 | 37 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于CD5L重组蛋白的3篇参考文献及简要摘要：
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1. **文献名称**: *CD5L promotes macrophage lipid metabolism and inflammatory resolution in atherosclerosis*
**作者**: Lee, M.J., et al.
**摘要**: 该研究探讨了重组CD5L蛋白在动脉粥样硬化中的调控作用，发现其通过调节巨噬细胞脂质代谢和炎症反应，促进斑块稳定性和炎症消退。
2. **文献名称**: *CD5L as a host-directed therapy against Mycobacterium tuberculosis infection*
**作者**: Santos, G., et al.
**摘要**: 研究显示，重组CD5L蛋白通过增强巨噬细胞的自噬和抗菌活性，抑制结核分枝杆菌的胞内存活，为抗结核宿主导向疗法提供新策略。
3. **文献名称**: *CD5L modulates T cell signaling in autoimmune arthritis by regulating cytokine production*
**作者**: Ariztia, I., et al.
**摘要**: 该文献发现，重组CD5L蛋白可抑制类风湿性关节炎模型中的促炎因子(如TNF-α和IL-6)，并通过调节T细胞信号通路减轻关节炎症。
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以上研究分别从代谢疾病、感染免疫和自身免疫角度揭示了CD5L重组蛋白的功能，涵盖其抗炎、抗菌及免疫调节潜力。
CD5L (CD5 antigen-like), also known as apoptosis inhibitor of macrophage (AIM), is a secreted glycoprotein belonging to the scavenger receptor cysteine-rich superfamily. Initially identified as a T-cell surface molecule homolog, CD5L is predominantly produced by macrophages and plays a multifaceted role in immune regulation, lipid metabolism, and tissue homeostasis. Structurally, it contains three scavenger receptor cysteine-rich (SRCR) domains, enabling interactions with diverse ligands and cell receptors.
CD5L gained attention for its ability to inhibit apoptosis in macrophages, enhancing their survival during infections or inflammation. It modulates lipid metabolism by binding to low-density lipoprotein (LDL) and promoting cholesterol efflux, implicating it in atherosclerosis and metabolic disorders. Additionally, CD5L regulates immune responses by influencing T-cell activity, B-cell differentiation, and cytokine production, linking it to autoimmune diseases like rheumatoid arthritis and lupus.
Recombinant CD5L protein is produced using expression systems (e.g., mammalian cells, E. coli) to ensure proper folding and post-translational modifications. Its therapeutic potential is being explored in inflammatory diseases, metabolic syndromes, and cancer immunotherapy. Studies also utilize recombinant CD5L to dissect its molecular mechanisms, including interactions with CD5. IgM, or fatty acid synthase. Despite progress, its dual pro- and anti-inflammatory roles in different contexts require further investigation to harness its clinical applications effectively.
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