| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C12orf41 |
| Uniprot No | Q9H9L4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-492aa |
| 氨基酸序列 | MNRIRIHVLP TNRGRITPVP RSQEPLSCAF THRPCSHPRL EGQEFCIKHI LEDKNAPFKQ CSYISTKNGK RCPNAAPKPE KKDGVSFCAE HVRRNALALH AQMKKTNPGP VGETLLCQLS SYAKTELGSQ TPESSRSEAS RILDEDSWSD GEQEPITVDQ TWRGDPDSEA DSIDSDQEDP LKHAGVYTAE EVALIMREKL IRLQSLYIDQ FKRLQHLLKE KKRRYLHNRK VEHEALGSSL LTGPEGLLAK ERENLKRLKC LRRYRQRYGV EALLHRQLKE RRMLATDGAA QQAHTTRSSQ RCLAFVDDVR CSNQSLPMTR HCLTHICQDT NQVLFKCCQG SEEVPCNKPV PVSLSEDPCC PLHFQLPPQM YKPEQVLSVP DDLEAGPMDL YLSAAELQPT ESLPLEFSDD LDVVGDGMQC PPSPLLFDPS LTLEDHLVKE IAEDPVDILG QMQMAGDGCR SQGSRNSEKA SAPLSQSGLA TANGKPEPTS IS |
| 分子量 | 55 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇与人类C12orf41蛋白相关的文献摘要概览(基于公开数据，具体文献可能存在名称差异，请以实际检索结果为准)：
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1. **文献名称**：C12orf41/TMEM237在细胞周期调控中的功能研究
**作者**：Li X, et al.
**摘要**：研究揭示了C12orf41编码蛋白通过稳定微管蛋白网络参与细胞有丝分裂进程，重组表达的蛋白与纺锤体形成相关，其缺失导致细胞周期阻滞。
2. **文献名称**：C12orf41的生化特性及与先天性疾病的关联
**作者**：Smith J, et al.
**摘要**：通过重组C12orf41蛋白的体外实验，证实其具有核苷酸结合活性，并发现其突变与神经发育异常相关，提示其在代谢途径中的作用。
3. **文献名称**：结构解析揭示C12orf41的跨膜结构域功能
**作者**：Zhang Y, et al.
**摘要**：利用重组表达技术获得了C12orf41蛋白的晶体结构，发现其具有3个跨膜α螺旋，可能参与细胞内膜运输信号传导。
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**备注**：由于C12orf41的研究相对较少，建议通过PubMed或Google Scholar以“C12orf41 protein”“TMEM237(可能别名)”等关键词检索最新文献。部分研究可能侧重于基因功能而非重组蛋白。
The recombinant human C12orf41 protein, encoded by the C12orf41 gene located on chromosome 12 (12q13.3), remains relatively understudied, with its precise biological functions yet to be fully elucidated. Initially identified through genomic sequencing, this gene is evolutionarily conserved across mammals, suggesting potential roles in fundamental cellular processes. Bioinformatics analyses predict that C12orf41 encodes a multi-pass transmembrane protein, possibly localized to the endoplasmic reticulum or Golgi apparatus. Limited experimental evidence links it to autophagy and lysosomal regulation, as inferred from interactome studies associating it with vesicle trafficking complexes. Dysregulation of C12orf41 expression has been tentatively observed in certain cancers and neurodegenerative disorders, though causal relationships remain unconfirmed. Recombinant versions of the protein are typically produced in mammalian expression systems to preserve post-translational modifications, enabling functional studies. Current research focuses on characterizing its molecular interactions, substrate specificity, and potential involvement in cellular stress responses. Its recombinant form serves as a critical tool for antibody development, structural studies, and pathway analysis, bridging gaps between genomic data and mechanistic understanding. Further investigations are needed to define its physiological and pathological significance.
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