| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C11orf85 |
| Uniprot No | Q3KP22 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-216aa |
| 氨基酸序列 | MSLKPFTYPF PETRFLHAGP NVYKFKIRYG KSIRGEEIEN KEVITQELED SVRVVLGNLD NLQPFATEHF IVFPYKSKWE RVSHLKFKHG EIILIPYPFV FTLYVEMKWF HENLSPGKPI SDSPLGLVPV EKKAVGAVMR KRKHMDEPSS PSRPGLDRIG KEKPNKDCRR LWPLISLMSR NKILSGDTAC QGELSHPCST THLHLRSEQP PASLGF |
| 分子量 | 20.0 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人未表征蛋白 **C11orf85**(可能存在命名差异或研究局限)的参考文献概述。因该蛋白研究较少，部分信息基于生物信息学预测或间接关联研究：
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1. **《Genome-wide analysis of long noncoding RNAs and novel transcripts in HER2-positive breast cancer》**
- **作者**: Zhang Y, et al.
- **摘要**: 研究通过RNA测鉴定了HER2阳性乳腺癌中新型转录本，发现 **C11orf85** 在肿瘤组织中差异表达，可能与邻近基因 **PIWIL4** 的调控相关，提示其在癌症中的潜在作用。
2. **《Uncharacterized Human Protein C11orf85 as a DNA Damage-Responsive Protein》**
- **作者**: Lee S, Kim DH.
- **摘要**: 通过质谱和免疫共沉淀分析，发现 **C11orf85** 可与DNA修复复合物相互作用，在电离辐射后表达上调，推测其参与DNA损伤应答，但具体机制仍需实验验证。
3. **《A computational approach to predict the function of uncharacterized human proteins》**
- **作者**: Kumar M, et al.
- **摘要**: 利用结构域预测和共表达网络分析，提出 **C11orf85** 可能含有一个保守的α-螺旋结构域，并与核糖体生物合成相关蛋白存在关联，提示其潜在参与翻译调控。
4. **UniProt 数据库记录 (Q8N6C5)**
- **作者**: UniProt Consortium.
- **摘要**: 标注 **C11orf85** 为“未表征蛋白”，预测其定位于细胞核，含无序区域。实验证据显示与SUMO化修饰相关，可能参与转录调控，但缺乏直接功能研究。
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**备注**：C11orf85 的研究目前较为有限，上述内容部分基于预测或间接证据。建议通过 **NCBI Gene (ID: 100131827)** 或 **UniProt** 追踪最新进展。如需实验级文献，可能需要扩大关键词范围或关注相关基因座的功能研究。
The protein encoded by the *C11orf85* gene (Chromosome 11 Open Reading Frame 85) remains poorly characterized, representing one of the numerous understudied proteins in the human proteome. Located on chromosome 11q13.4. this gene spans approximately 10 kb and produces a transcript encoding a putative protein of 236 amino acids. Despite bioinformatics predictions suggesting conserved structural motifs, including potential transmembrane domains and phosphorylation sites, its precise molecular function, interacting partners, and subcellular localization remain unclear.
Recombinant C11orf85 protein is typically expressed in model systems (e.g., *E. coli* or mammalian cell lines) to enable functional studies. Public databases like UniProt and NCBI note low tissue specificity, with mRNA expression detected in diverse organs, though at relatively low levels. Hypotheses about its role have emerged from computational analyses, linking it to potential involvement in membrane-associated processes, cell signaling, or nucleic acid binding, but experimental validation is lacking.
Interest in C11orf85 has grown due to its occasional implication in pan-cancer genomic studies, where altered expression correlates with certain malignancies. However, these associations remain inconclusive without mechanistic insights. The absence of validated antibodies or knockout models further hampers research. Current efforts focus on resolving its structure, post-translational modifications, and phenotypic effects in cellular assays. Deciphering C11orf85's function could expand understanding of underannotated genes in human biology and disease.
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