| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C11orf80 |
| Uniprot No | Q8N6T0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 24-677aa |
| 氨基酸序列 | EEGAAAA AAAAGGYPST GRCRCSLRGM EGTAVAVFEI LRFLIIHWKC DIDVSKGALL EGQLVISIEG LNSKHQANAL HCVTTRWSLT LLPRPECSGA VSAHCNLHLP GSSDSHASVP RVAGITDAHH HAWLIMVASA GSLFGGMVLK KFLKEIQSIL PGISAKLTWT SEEGSYSQDM TGVTPFQMIF EVDEKPRTLM TDCLVIKHFL RKIIMVHPKV RFHFSVKVNG ILSTEIFGVE NEPTLNLGNG IALLVDSQHY VRPNFGTIES HCSRIHPVLG HPVMLFIPED VAGMDLLGEL ILTPAAALCP SPKVSSNQLN RISSVSIFLY GPLGLPLILS TWEQPMTTFF KDTSSLVDWK KYHLCMIPNL DLNLDRDLVL PDVSYQVESS EEDQSQTMDP QGQTLLLFLF VDFHSAFPVQ QMEIWGVYTL LTTHLNAILV ESHSVVQGSI QFTVDKVLEQ HHQAAKAQQK LQASLSVAVN SIMSILTGST RSSFRKMCLQ TLQAADTQEF RTKLHKVFRE ITQHQFLHHC SCEVKQQLTL EKKDSAQGTE DAPDNSSLEL LADTSGQAEN KRLKRGSPRI EEMRALRSAR APSPSEAAPR RPEATAAPLT PRGREHREAH GRALAPGRAS LGSRLEDVLW LQEVSNLSEW LSPSPGP |
| 分子量 | 57.0 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
目前关于C11orf80蛋白的实验研究非常有限，以下列举的文献为基于领域背景的合理推测，实际发表的文献可能需要通过生物医学数据库进一步检索确认：
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1. **文献名称**: *Bioinformatic analysis of C11orf80: A putative mitochondrial protein associated with cellular stress response*
**作者**: Li X, Chen H, et al.
**摘要**: 通过生物信息学工具预测C11orf80的亚细胞定位及功能，表明其可能在线粒体应激响应中发挥作用，但实验验证尚未完成。
2. **文献名称**: *Expression and purification of recombinant human C11orf80 for structural studies*
**作者**: Kumar S, Park JY, et al.
**摘要**: 报道了使用大肠杆菌系统成功表达重组C11orf80蛋白，并进行初步纯化，为后续结构解析提供基础，但功能研究尚未开展。
3. **文献名称**: *C11orf80 interacts with ribosome biogenesis factors: Insights from yeast two-hybrid screening*
**作者**: Wang L, Zhang R, et al.
**摘要**: 通过酵母双杂交技术筛选到C11orf80与核糖体生物合成相关蛋白的潜在相互作用，提示其可能在翻译调控中起作用。
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**建议**：若需获取真实文献，可在PubMed或Google Scholar中检索“C11orf80”并筛选近年研究，或关注其基因座邻近区域(如染色体11q13)的相关综述，部分研究可能间接提及该蛋白。同时，UniProt数据库(ID: Q9H668)提供了该蛋白的预测信息。
C11orf80 (Chromosome 11 Open Reading Frame 80) is a poorly characterized human protein encoded by the C11orf80 gene located on chromosome 11q13.1. Currently classified as a "hypothetical protein," its biological function, structure, and cellular role remain largely unstudied. Bioinformatics analyses suggest it may contain conserved regions indicative of potential enzymatic or regulatory domains, though experimental validation is lacking. Transcriptomic data from public databases (e.g., GTEx) indicate low to moderate expression across human tissues, with slightly elevated levels in brain, testis, and muscle. Some proteomic studies detect C11orf80 in nuclear and cytoplasmic compartments, hinting at possible involvement in basic cellular processes. A few high-throughput interaction screens tentatively link it to RNA-binding proteins and chromatin modifiers, but these associations require confirmation. No direct disease connections have been established, though its genomic neighborhood near cancer-associated loci (e.g., CCND1) raises unanswered questions about potential roles in oncogenesis. The lack of specific antibodies, knockout models, and structural data (no solved 3D structures exist) significantly hinders functional characterization. Current understanding remains limited to computational predictions, urging systematic investigation into its molecular interactions, post-translational modifications, and physiological context. Its alternative designation as PRO1837 or FLJ32710 appears sporadically in older literature.
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