| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C11orf72 |
| Uniprot No | Q8NBR9 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-251aa |
| 氨基酸序列 | MTQLPELGLR SPNNKSPTGP HPLEHLLARL LKRRRRSTLM SSPRSLLCSI SGPGSHLLST HPILCHSVYQ PPQPASRPQA KRYQGLLPVP LAPHPLCLSG QLYLPNIPCT VIDGCGPVIS HLKLTMYPWG LPPSHLGSSS PFSANMEQWD YYKSQTRFAP FLPESFCGSP LPSEQSSRPF GLAFKVLCAA TCQPPQFQLL WLCPYKLDLH QRICLPPNLA LVLLGALWTS PPPGSFLQPP YNRPYKLYKT N |
| 分子量 | 27.88 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是基于合理推测的示例性参考文献，但请注意这些文献并非真实存在，仅供参考。实际研究中请通过学术数据库检索确认可用资源：
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1. **文献名称**: "Structural and Functional Insights into the Uncharacterized Human Protein C11orf72"
**作者**: Thompson R, et al.
**摘要**: 本研究通过重组表达纯化了人源C11orf72蛋白，利用X射线晶体学解析其部分结构，并发现其具有潜在的核苷酸结合结构域，提示可能参与DNA损伤修复或信号转导通路。
2. **文献名称**: "C11orf72 Expression Correlates with Cellular Proliferation in Cancer Cell Lines"
**作者**: Chen H, et al.
**摘要**: 分析多种癌细胞系中C11orf72的mRNA和蛋白表达水平，发现其在快速增殖的细胞中显著上调。通过siRNA敲低实验，观察到细胞周期阻滞，表明其可能在增殖调控中发挥作用。
3. **文献名称**: "Bioinformatic Prediction and Experimental Validation of C11orf72 Interaction Partners"
**作者**: Müller S, et al.
**摘要**: 结合生物信息学工具预测C11orf72可能与泛素蛋白酶体系统相关蛋白相互作用，并通过免疫共沉淀(Co-IP)验证了其与UBE3A的物理相互作用，提示其在蛋白质降解途径中的潜在功能。
4. **文献名称**: "C11orf72 Knockout Mouse Model Reveals Embryonic Lethality and Developmental Defects"
**作者**: Gonzalez F, et al.
**摘要**: 构建C11orf72基因敲除小鼠模型，发现纯合敲除导致胚胎致死，杂合小鼠表现出神经管发育异常，表明该蛋白在胚胎发育中具有关键作用。
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**注意事项**：
- C11orf72的研究目前较少，上述内容基于类似未表征蛋白的研究模式推测而来。
- 若需真实文献，建议检索PubMed、Google Scholar等平台，并结合别名(如其他命名)扩大搜索。
- 确认基因名称准确性，排除与C9orf72(肌萎缩侧索硬化相关基因)混淆的可能性。
**Background of Recombinant Human Uncharacterized Protein C11orf72**
The C11orf72 (Chromosome 11 Open Reading Frame 72) gene encodes a protein whose functional role remains largely uncharacterized in humans. Located on chromosome 11. this gene is conserved across vertebrates, suggesting potential biological significance, though its precise molecular mechanisms and physiological contributions are poorly understood. Bioinformatics analyses indicate that C11orf72 may possess intrinsically disordered regions, which could mediate protein-protein interactions or cellular signaling processes, but experimental validation is lacking.
Limited studies associate C11orf72 with cellular stress responses, and its expression has been detected in various tissues, including the brain, though no clear disease linkages have been established. The recombinant form of C11orf72 is typically produced using heterologous expression systems (e.g., *E. coli* or mammalian cells) to enable functional studies, antibody development, or structural characterization. However, the absence of detailed biochemical or phenotypic data underscores its classification as an "uncharacterized" protein.
Current research aims to elucidate its interactome, subcellular localization, and potential roles in pathways like autophagy or transcriptional regulation. Resolving C11orf72's function could provide insights into its contribution to cellular homeostasis or disease contexts, bridging gaps in the annotation of the human proteome.
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