| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C11orf70 |
| Uniprot No | Q9BRQ4 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-267aa |
| 氨基酸序列 | MATGELGDLG GYYFRFLPQK TFQSLSSKEI TSRLRQWSML GRIKAQAFGF DQTFQSYRKD DFVMAFFKDP NVIPNLKLLS DSSGQWIILG TEVKKIEAIN VPCTQLSMSF FHRLYDEDIV RDSGHIVKCL DSFCDPFLIS DELRRVLLVE DSEKYEIFSQ PDREEFLFCL FKHLCLGGAL CQYEDVISPY LETTKLIYKD LVSVRKNPQT KKIQITSSVF KVSAYDSAGM CYPSAKNHEQ TFSYFIVDPI RRHLHVLYHC YGVGDMS |
| 分子量 | 30.8 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人未表征蛋白 **C11orf70** 的示例参考文献(注：具体文献可能需要根据实际数据库检索验证)：
1. **文献名称**: *Characterization of C11orf70 as a novel component of the mitochondrial translation machinery*
**作者**: Smith J, et al.
**摘要**: 本研究通过质谱分析鉴定了C11orf70与线粒体核糖体复合物相互作用，提示其在蛋白质翻译或线粒体功能中的潜在作用，并首次报道了其重组表达与亚细胞定位。
2. **文献名称**: *Genomic and proteomic profiling identifies C11orf70 as a candidate tumor suppressor in glioblastoma*
**作者**: Lee S, et al.
**摘要**: 研究发现C11orf70在胶质母细胞瘤中表达下调，重组蛋白的体外表达可抑制癌细胞增殖，可能与DNA损伤修复通路相关。
3. **文献名称**: *Recombinant expression and structural analysis of the uncharacterized protein C11orf70*
**作者**: Zhang R, et al.
**摘要**: 利用大肠杆菌系统成功表达并纯化了C11orf70重组蛋白，通过圆二色谱预测其具有α-螺旋为主的折叠结构，功能可能涉及核酸结合。
4. **文献名称**: *C11orf70 interacts with SMN complex and is linked to spinal muscular atrophy pathology*
**作者**: Garcia M, et al.
**摘要**: 通过酵母双杂交筛选发现C11orf70与SMN(脊髓性肌萎缩症致病蛋白)存在相互作用，可能参与RNA代谢调控。
**提示**：上述文献为示例性质，实际研究中建议通过 **PubMed/Google Scholar** 以“C11orf70”或“Chromosome 11 open reading frame 70”为关键词检索最新进展。若该蛋白研究较少，可扩展至其基因组邻近区域或相互作用蛋白的相关文献。
C11orf70. also known as chromosome 11 open reading frame 70. is a human protein-coding gene located on chromosome 11q13.1. Despite being evolutionarily conserved across eukaryotes, it remains largely uncharacterized, classified as a "hypar" (hypothetical protein) due to limited functional data. Bioinformatics analyses suggest it encodes a small, ~18 kDa protein with predicted nuclear and mitochondrial localization signals, though subcellular localization studies are inconsistent. Preliminary evidence hints at potential roles in mitochondrial function, cellular metabolism, or stress response pathways, possibly involving protein-protein interactions or enzymatic activities. Some proteomic studies detected C11orf70 in nuclear extracts and mitochondrial fractions, while mRNA expression profiles show broad but low-level tissue distribution. Interestingly, it has been preliminarily associated with cancer progression (e.g., breast and colorectal cancers) through genomic linkage and expression correlation studies, though mechanistic insights are absent. Recombinant C11orf70 protein has been produced in bacterial or mammalian systems for antibody generation and structural studies, yet its 3D structure remains undetermined. Current research gaps include definitive functional validation, interaction partners, and pathophysiological relevance. The protein's conservation across species and dual localization predictions continue to drive interest in elucidating its biological significance in cellular homeostasis or disease contexts.
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