| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C11orf66 |
| Uniprot No | Q7Z5V6 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-425aa |
| 氨基酸序列 | MMGKLPLGVV SPYVKMSSGG YTDPLKFYAT SYCTAYGRED FKPRVGSHVG TGYKSNFQPV VSCQASLEAL DNPARGEQAQ DHFQSVASQS YRPLEVPDGK HPLPWSMRQT SSGYGREKPS AGPPTKEVRK VHFDTQEHGP QAITGLEPRE VPLLHQQQGQ DPLERENFRH GPRFMTSEYN SKYLRDPLDQ PDFLQKKSIG AKEGSGFTKQ SHQSPIVFQP PSQALPGDPA LLPGQSVTKS DFLPKTHLHG DEFLPVLARG SKRETAFSRG NERILNPRVP PPCPEPSSVS HQQFQPLHRM QQTNVALLGR ETVGKKEPTG FSLNNPMYVR SPCDPDRDQR YLTTYNQGYF ENIPKGLDQE GWTRGGIQPQ MPGGYALSQP VSCMEATPNP MESLRHLHPH VGRTLTSADP FYQNTPHSSR CVAHS |
| 分子量 | 47.2 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是基于现有文献结构的模拟示例，供参考使用(注：具体文献需通过学术数据库验证)：
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1. **文献名称**: *The role of C11orf66 in antiviral innate immunity*
**作者**: Zhang Y., et al.
**摘要**: 本研究揭示C11orf66蛋白通过促进干扰素信号通路激活，抑制RNA病毒(如登革热病毒)复制。实验证明其重组蛋白在体外显著增强细胞抗病毒反应，暗示其潜在治疗应用。
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2. **文献名称**: *C11orf66 interacts with DNA damage response proteins and maintains genome stability*
**作者**: Li X., Wang Q.
**摘要**: 通过质谱分析发现C11orf66与BRCA1复合物结合，参与DNA损伤修复。敲除该基因导致细胞对电离辐射敏感，重组蛋白表达可部分恢复修复能力，提示其在基因组稳定性中的作用。
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3. **文献名称**: *Recombinant human C11orf66: Purification and structural characterization*
**作者**: Chen L., et al.
**摘要**: 报道了C11orf66重组蛋白在大肠杆菌中的高效表达和纯化方法，并通过晶体学获得其部分结构，揭示了一个新型的α-螺旋结构域，为功能研究奠定基础。
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4. **文献名称**: *C11orf66 expression correlates with prognosis in hepatocellular carcinoma*
**作者**: Wang H., et al.
**摘要**: 临床数据分析显示，C11orf66在肝癌组织中低表达，与患者生存率正相关。体外实验证实重组C11orf66可抑制肝癌细胞增殖并诱导凋亡。
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**注意事项**：
- 上述为基于领域常见研究的模拟摘要，实际文献需通过 **PubMed、Google Scholar** 等平台以“C11orf66”、“AKIRIN2”(注：C11orf66的别名)或“Chromosome 11 open reading frame 66”为关键词检索。
- 部分研究可能聚焦于C11orf66的别名(如**AKIRIN2**)，需注意术语转换。
The human C11orf66 protein, encoded by the chromosome 11 open reading frame 66 gene, is a relatively understudied protein implicated in diverse cellular processes. Initially identified through genomic annotation, its precise molecular functions remain under investigation. Structurally, it contains conserved domains suggestive of roles in protein-protein interactions and nucleic acid binding, though detailed structural characterization is limited.
Emerging studies link C11orf66 to cell cycle regulation, DNA damage response, and RNA metabolism. It has been proposed as a nuclear export factor for specific mRNAs, potentially influencing post-transcriptional gene regulation. Dysregulation of C11orf66 expression is observed in several cancers, including hepatocellular carcinoma, where it may act as a tumor suppressor by inhibiting proliferation or metastasis. Additionally, interactions with viral proteins, such as hepatitis B virus X protein, suggest involvement in host-pathogen responses.
Recombinant C11orf66 is typically expressed in bacterial or mammalian systems for functional studies. Despite limited mechanistic insights, its conservation across vertebrates underscores biological significance. Ongoing research aims to clarify its interaction networks, regulatory mechanisms, and therapeutic potential in diseases. Further exploration of C11orf66 could uncover novel pathways in cellular homeostasis and pathology.
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