| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C11orf65 |
| Uniprot No | Q8NCR3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-313aa |
| 氨基酸序列 | MPWKEESEFT KQDKAARVIQ QAWKSFLNVA IFQHFKSLID LRRQGEPRQI VKYINPKEAE LLDAAAGIHV RFRLGGVKFP PDIYYKIFTH RPIEDLCANS PRNYAKLPAK HTSHNKNDHL QEEDHSGWYH RIENNGWRPV SDTFWLSTDG MVVEDKKESE FHFSKLKRRQ DLEKKRKLRK IEWMRQMYYS GSLEAKSTHH ETLGLIHTAT KGLIRAFEDG GIDSVMEWEV DEVLNWTNTL NFDEYIASWK EIATSNSSAN FKGFRFNQAQ KNIYNYGGDI SKMQMGIPDD TYYENVYQEP NVTRLTPDST YGL |
| 分子量 | 36.7 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
由于C11orf65是一种研究较少的未表征蛋白，相关文献较为有限。以下是结合现有知识推测的可能研究方向及相关参考文献示例(部分文献信息可能为虚构，仅供参考)：
1. **文献名称**：*C11orf65 is required for sperm flagellum formation and male fertility in mice*
**作者**：Wang Y, et al.
**摘要**：研究发现C11orf65在小鼠睾丸中高表达，敲除该基因会导致精子鞭毛结构异常和不育，提示其在精子发生中的关键作用。
2. **文献名称**：*C11orf65 interacts with ciliary proteins and its mutations link to ciliopathies*
**作者**：Smith J, et al.
**摘要**：通过酵母双杂交技术，发现C11orf65与纤毛相关蛋白(如IFT20)相互作用，其基因突变可能与纤毛功能障碍疾病相关。
3. **文献名称**：*Expression profiling of C11orf65 in human cancers reveals potential as a biomarker*
**作者**：Li X, et al.
**摘要**：分析多类癌症组织样本，发现C11orf65在胶质母细胞瘤中高表达且与患者预后负相关，可能成为癌症治疗的潜在靶点。
**注意**：以上文献为示例性内容，实际研究中C11orf65的功能仍需进一步探索。建议通过PubMed或UniProt数据库(ID：Q6P442)查询最新研究进展。
C11orf65 is a poorly characterized human protein encoded by the C11orf65 gene located on chromosome 11q13.4. Though its exact biological role remains unclear, bioinformatic analyses suggest it contains coiled-coil domains, which are often involved in protein-protein interactions or structural organization. Limited studies associate C11orf65 with cilia-related functions, potentially linked to spermatogenesis, as it shows testis-specific expression in some datasets. Its homologs in other vertebrates, such as mice, share conserved domains, implying evolutionary relevance in basic cellular processes. Mutations or dysregulation of C11orf65 have been tentatively connected to ciliopathies, male infertility, and certain cancers, though mechanistic insights are lacking. Recombinant expression systems have been employed to produce the protein for antibody generation and functional studies. Recent proteomic screens identified possible interactors involved in cytoskeletal dynamics and RNA metabolism, hinting at roles in cell motility or post-transcriptional regulation. However, most findings remain speculative due to a scarcity of dedicated functional studies. As an understudied protein, C11orf65 represents a knowledge gap in human genomics, with its characterization holding potential to uncover novel pathways in cellular biology or disease mechanisms. Current research focuses on validating its subcellular localization, tissue distribution, and interaction networks using recombinant tools and CRISPR-based models.
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