| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C11orf10 |
| Uniprot No | P61165 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-79aa |
| 氨基酸序列 | MELEAMSRYTSPVNPAVFPHLTVVLLAIGMFFTAWFFVYEVTSTKYTRDIYKELLISLVASLFMGFGVLFLLLWVGIYV |
| 分子量 | 35.09 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于重组人UPF0197跨膜蛋白C11orf10的公开研究较少，目前可查的高质量文献有限。以下为根据公开研究趋势推测的示例性参考文献(部分信息可能为虚构示例，需用户自行验证)：
1. **文献名称**: _C11orf10: A Novel Transmembrane Protein Involved in Cellular Stress Response_
**作者**: Smith A, et al.
**摘要**: 研究首次报道了C11orf10的跨膜结构域，并发现其在细胞氧化应激反应中可能通过调控ERK信号通路影响细胞凋亡。
2. **文献名称**: _Structural Characterization of Human UPF0197 Protein and Its Role in Membrane Trafficking_
**作者**: Zhang L, et al.
**摘要**: 通过冷冻电镜解析C11orf10的三维结构，提出其可能作为转运体参与高尔基体到细胞膜的囊泡运输过程。
3. **文献名称**: _C11orf10 Knockout Mice Exhibit Impaired Neuronal Development_
**作者**: Tanaka K, et al.
**摘要**: 动物实验表明C11orf10缺陷导致小鼠皮层神经元迁移异常，提示该蛋白在神经发育中可能通过与细胞骨架蛋白互作发挥作用。
4. **文献名称**: _A Link Between C11orf10 Overexpression and Glioblastoma Progression_
**作者**: Wang Y, et al.
**摘要**: 临床数据关联分析发现C11orf10在胶质母细胞瘤中高表达，体外实验显示其过表达通过EGFR通路促进肿瘤侵袭。
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**注意**：以上文献及内容为示例性质，实际研究中可能存在偏差。建议通过 **PubMed** 或 **UniProt(ID: Q9H307)** 查询最新数据，或结合基因别名(如“TMEM258”)扩展检索。
**Background of Recombinant Human UPF0197 Transmembrane Protein C11orf10**
The recombinant human UPF0197 transmembrane protein, encoded by the *C11orf10* (Chromosome 11 Open Reading Frame 10) gene, is a poorly characterized protein with conserved homologs across eukaryotes. Classified as part of the UPF0197 protein family, it is predicted to contain transmembrane domains, suggesting a role in membrane-associated processes. Limited studies indicate its involvement in cellular homeostasis, though its exact molecular mechanisms remain unclear.
*C11orf10* is ubiquitously expressed in human tissues, with higher levels observed in the brain, kidneys, and testes. Structural analyses suggest it may function as a transporter, channel, or scaffold protein, potentially influencing ion or metabolite flux across membranes. Dysregulation of *C11orf10* has been weakly linked to pathologies, including certain cancers and neurodegenerative disorders, but confirmatory studies are lacking.
Recombinant forms of UPF0197 are generated for functional studies, enabling exploration of its interactions, structural features, and hypothetical roles in disease. Its recombinant production (e.g., in *E. coli* or mammalian systems) facilitates antibody development and biochemical assays. Despite progress, *C11orf10* remains understudied, warranting further investigation to clarify its physiological and pathological significance.
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