| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C10orf9 |
| Uniprot No | Q8ND76 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 2-341aa |
| 氨基酸序列 | GNTTSCCVS SSPKLRRNAH SRLESYRPDT DLSREDTGCN LQHISDRENI DDLNMEFNPS DHPRASTIFL SKSQTDVREK RKSLFINHHP PGQIARKYSS CSTIFLDDST VSQPNLKYTI KCVALAIYYH IKNRDPDGRM LLDIFDENLH PLSKSEVPPD YDKHNPEQKQ IYRFVRTLFS AAQLTAECAI VTLVYLERLL TYAEIDICPA NWKRIVLGAI LLASKVWDDQ AVWNVDYCQI LKDITVEDMN ELERQFLELL QFNINVPSSV YAKYYFDLRS LAEANNLSFP LEPLSRERAH KLEAISRLCE DKYKDLRRSA RKRSASADNL TLPRWSPAII S |
| 分子量 | 39.3 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人C10orf9蛋白的假设性文献示例(仅供参考，非真实文献)：
1. **文献名称**：*Cloning and Expression of Human C10orf9 Protein in Escherichia coli*
**作者**：Zhang L, et al.
**摘要**：报道了C10orf9基因的克隆及在大肠杆菌中的重组表达，通过亲和层析纯化获得高纯度蛋白，并验证其正确折叠。
2. **文献名称**：*C10orf9 Interacts with Histone Deacetylases and Regulates Cell Cycle Progression*
**作者**：Kim S, et al.
**摘要**：首次发现C10orf9与组蛋白去乙酰化酶(HDACs)相互作用，调控细胞周期G1/S期转换，提示其表观遗传调控作用。
3. **文献名称**：*C10orf9 Overexpression in Colorectal Cancer and Its Pro-tumorigenic Function*
**作者**：Wang Y, et al.
**摘要**：通过免疫组化分析发现C10orf9在结直肠癌中高表达，体外实验显示其促进癌细胞迁移和侵袭，可能作为潜在治疗靶点。
4. **文献名称**：*Structural Insights into the DNA-binding Activity of C10orf9*
**作者**：Tanaka K, et al.
**摘要**：利用X射线晶体学解析C10orf9蛋白结构，发现其N端含DNA结合域，可能参与DNA损伤修复通路。
**注**：上述文献为模拟内容，实际研究中C10orf9的功能可能与假设不同。建议通过PubMed或Google Scholar以“C10orf9”或“FAM107B”(其潜在别名)为关键词检索最新文献。
The human C10orf9 protein, encoded by the chromosome 10 open reading frame 9 gene, remains poorly characterized, though emerging studies suggest its potential roles in cellular regulation and disease. This protein, also tentatively termed MGC29643 or LIPA2. is evolutionarily conserved across vertebrates but lacks detailed structural or functional annotations. Predicted to localize to the nucleus or mitochondria, in silico analyses indicate possible involvement in cell cycle control, apoptosis, or signal transduction, though experimental validation is limited.
Recombinant C10orf9 protein is engineered for functional studies, enabling antibody production, interaction mapping, and pathway analysis. Preliminary evidence links it to cancer progression, with altered expression observed in gliomas and breast cancers, possibly influencing tumor proliferation or metastasis. Additionally, its upregulated expression in neuronal tissues hints at neurodevelopmental or degenerative roles.
Current challenges include resolving its 3D structure, post-translational modifications, and precise mechanistic contributions to physiology. As a poorly studied "orphan" protein, C10orf9 represents an intriguing target for uncovering novel biological pathways or therapeutic strategies, particularly in oncology and neurology. Further research using recombinant tools may clarify its molecular interactions and disease relevance.
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