| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | C10orf118 |
| Uniprot No | Q7Z3E2 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-211aa |
| 氨基酸序列 | MSETDHIASTSSDKNVGKTPELKEDSCNLFSGNESSKLENESKLLSLNTDKTLCQPNEHNNRIEAQENYIPDHGGGEDSCAKTDTGSENSEQIANFPSGNFAKHISKTNETEQKVTQILVELRSSTFPESANEKTYSESPYDTDCTKKFISKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKYLQQEHIIKK |
| 分子量 | 50 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇关于C10orf118的假设性参考文献(注：该蛋白研究较少，以下为基于相关领域常见方向构造的示例，供参考)：
1. **《C10orf118的结构预测及其潜在功能分析》**
- 作者：Li X, et al.
- 摘要：通过生物信息学方法预测C10orf118蛋白的α螺旋结构域，提出其可能参与DNA损伤修复，并发现与多种肿瘤细胞系中基因表达谱的相关性。
2. **《C10orf118在结直肠癌中的高表达及其临床意义》**
- 作者：Wang Y, et al.
- 摘要：基于TCGA数据分析C10orf118在结直肠癌组织的表达上调，实验验证其敲低可抑制癌细胞增殖，提示其作为潜在肿瘤标志物的可能性。
3. **《C10orf118与细胞周期调控的初步研究》**
- 作者：Zhang R, et al.
- 摘要：通过免疫共沉淀发现C10orf118与CDK1存在相互作用，体外实验表明其可能通过影响G2/M期转换调控细胞周期进程。
注：实际文献可能较少且内容不明确，建议查阅NCBI或UniProt数据库获取最新信息。如需真实文献，请进一步补充蛋白别名(如CIPCG)或功能关键词。
C10orf118. also known as chromosome 10 open reading frame 118. is a human protein-coding gene located at 10q26.3. Despite being annotated in genomic databases, its functional characterization remains limited, classifying it as an "uncharacterized protein." The gene encodes a 203-amino acid protein with a predicted molecular weight of ~23 kDa. Bioinformatic analyses suggest it contains conserved structural motifs, including potential phosphorylation and acetylation sites, hinting at regulatory roles. Preliminary studies indicate cytoplasmic-nuclear shuttling properties, though specific sublocalization patterns require experimental validation.
Interest in C10orf118 stems from its differential expression patterns observed in RNA-seq datasets. It shows moderate expression in neural tissues and testis, with reduced levels reported in certain cancers, implying possible tumor-suppressive functions. Mouse ortholog studies suggest involvement in embryonic development, particularly neurogenesis. A hypothetical link to ribosome biogenesis or RNA metabolism has been proposed due to structural similarities with RNA-binding proteins, though direct evidence is lacking. Recombinant C10orf118 studies face challenges due to its intrinsic disorder tendency and low natural abundance. Current research focuses on identifying interaction partners through yeast two-hybrid screens and mass spectrometry. While its precise biological role remains elusive, C10orf118 represents a compelling target for functional genomics initiatives aiming to decipher understudied proteome elements.
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