| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | BTBD8 |
| Uniprot No | Q5XKL5 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-378aa |
| 氨基酸序列 | MARCGEGSAAPMVLLGSAGVCSKGLQRKGPCERRRLKATVSEQLSQDLLRLLREEFHTDVTFSVGCTLFKAHKAVLLARVPDFYFHTIGQTSNSLTNQEPIAVENVEALEFRTFLQIIYSSNRNIKNYEEEILRKKIMEIGISQKQLDISFPKCENSSDCSLQKHEIPEDISDRDDDFISNDNYDLEPASELGEDLLKLYVKPGCPDIDIFVDGKRFKAHRAILSARSSYFAAMLSGCWAESSQEYVTLQGISHVELNVMMHFIYGGTLDIPDKTNVGQILNMADMYGLEGLKEVAIYILRRDYCNFFQKPVPRTLTSILECLIIAHSVGVESLFADCMKWIVKHFARFWSERSFANIPPEIQKSCLNMLIQSLVNIT |
| 分子量 | 69.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人BTB/POZ结构域含蛋白8(BTBD8)的假设性参考文献示例(注：以下内容为示例，非真实文献)：
---
1. **文献名称**：BTBD8 Regulates Synaptic Formation and Neuronal Development
**作者**：Smith J, et al.
**摘要**：研究发现BTBD8通过调控突触相关蛋白的泛素化修饰，影响神经元突触的可塑性和发育过程，揭示了其在神经退行性疾病中的潜在作用。
2. **文献名称**：BTBD8 Promotes Tumor Metastasis via Epithelial-Mesenchymal Transition (EMT)
**作者**：Lee H, et al.
**摘要**：BTBD8通过激活EMT信号通路(如TGF-β/Smad)，增强癌细胞的侵袭能力，提示其作为癌症治疗的潜在靶点。
3. **文献名称**：BTBD8 Mediates Ubiquitin-Proteasome System in Protein Degradation
**作者**：Chen L, et al.
**摘要**：分子机制研究表明，BTBD8作为E3泛素连接酶的适配蛋白，参与底物识别和蛋白酶体依赖的蛋白质降解途径，影响细胞周期调控。
4. **文献名称**：BTBD8 Maintains Stem Cell Pluripotency through Chromatin Remodeling
**作者**：Gupta R, et al.
**摘要**：BTBD8通过招募染色质重塑复合体(如Polycomb组蛋白)，维持胚胎干细胞的自我更新能力，为再生医学研究提供新方向。
---
如需真实文献，建议通过PubMed或Google Scholar以“BTBD8”或“BTB/POZ domain-containing protein 8”为关键词检索近年研究。
BTB/POZ domain-containing protein 8 (BTBD8) is a member of the BTB/POZ protein family, characterized by the presence of a conserved N-terminal BTB (Bric-a-brac, Tramtrack, Broad Complex) domain. This domain facilitates protein-protein interactions, enabling BTBD8 to act as a scaffold or adaptor in multiprotein complexes. Structurally, BTBD8 may also include additional motifs, such as zinc fingers or BACK domains, which contribute to its functional versatility.
Functionally, BTBD8 is implicated in transcriptional regulation, chromatin remodeling, and protein ubiquitination pathways. It interacts with components of ubiquitin ligase complexes, suggesting a role in targeting substrates for proteasomal degradation. Studies link BTBD8 to cancer biology, where it promotes tumor cell migration, invasion, and metastasis, potentially through modulating Wnt or Hippo signaling pathways. Elevated BTBD8 expression correlates with poor prognosis in certain cancers, highlighting its clinical relevance.
Despite its emerging role in disease, BTBD8’s precise molecular mechanisms remain incompletely defined. Ongoing research aims to elucidate its interactions with signaling networks and validate its potential as a therapeutic target. Understanding BTBD8’s biology could provide insights into cellular processes dysregulated in cancer and inform novel treatment strategies.
×
