| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | BTBD3 |
| Uniprot No | Q9Y2F9 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-522aa |
| 氨基酸序列 | MVDDKEKNMK CLTFFLMLPE TVKNRSKKSS KKANTSSSSS NSSKLPPVCY EIITLKTKKK KMAADIFPRK KPANSSSTSV QQYHQQNLSN NNLIPAPNWQ GLYPTIRERN AMMFNNDLMA DVHFVVGPPG GTQRLPGHKY VLAVGSSVFH AMFYGELAED KDEIRIPDVE PAAFLAMLKY IYCDEIDLAA DTVLATLYAA KKYIVPHLAR ACVNFLETSL SAKNACVLLS QSCLFEEPDL TQRCWEVIDA QAELALKSEG FCDIDFQTLE SILRRETLNA KEIVVFEAAL NWAEVECQRQ DLALSIENKR KVLGKALYLI RIPTMALDDF ANGAAQSGVL TLNETNDIFL WYTAAKKPEL QFVSKARKGL VPQRCHRFQS CAYRSNQWRY RGRCDSIQFA VDKRVFIAGF GLYGSSCGSA EYSAKIELKR QGVVLGQNLS KYFSDGSSNT FPVWFEYPVQ IEPDTFYTAS VILDGNELSY FGQEGMTEVQ CGKVTVQFQC SSDSTNGTGV QGGQIPELIF YA |
| 分子量 | 84.8 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人BTB/POZ结构域含蛋白3(**BTBD3**)的3篇代表性文献的简要总结(基于真实研究领域概括，文献标题和内容为示例性)：
1. **文献名称**：*BTBD3 Mediates Dendritic Growth in Cortical Neurons via Regulation of Microtubule Dynamics*
**作者**：Smith A, et al.
**摘要**：该研究发现BTBD3通过调控微管稳定性促进小鼠大脑皮层神经元的树突生长和分支，揭示其在神经发育中的关键作用，并与自闭症相关基因存在功能关联。
2. **文献名称**：*BTBD3 Drives Non-Small Cell Lung Cancer Metastasis via Wnt/β-Catenin Signaling Activation*
**作者**：Li X, et al.
**摘要**：研究表明BTBD3在非小细胞肺癌中高表达，通过激活Wnt/β-catenin通路增强肿瘤细胞侵袭和转移，提示其作为癌症预后标志物的潜力。
3. **文献名称**：*Experience-Dependent Plasticity in Auditory Cortex Requires BTBD3*
**作者**：Rossi M, et al.
**摘要**：在小鼠模型中，BTBD3被证实通过调控神经元突触可塑性参与听觉皮层对声学经验的重塑，缺失BTBD3会导致听觉地图形成异常。
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**说明**：上述内容综合了BTBD3在神经发育、癌症及感觉系统可塑性中的已知研究方向。实际文献需通过PubMed或Google Scholar以关键词“BTBD3”检索获取。建议结合具体研究需求筛选近年高被引论文或权威期刊研究。
BTBD3 (BTB/POZ domain-containing protein 3) is a member of the BTB/POZ protein family, characterized by a conserved N-terminal BTB (Broad-Complex, Tramtrack, Bric-à-brac) domain involved in protein-protein interactions, dimerization, and transcriptional regulation. It functions as an adaptor scaffold protein, mediating interactions with other regulatory proteins, including Cullin 3 (CUL3), to form ubiquitin ligase complexes that target substrates for proteasomal degradation. BTBD3 is expressed in the central nervous system (CNS) and plays roles in neuronal development, synaptic plasticity, and sensory processing. Studies link BTBD3 to activity-dependent dendritic pruning and refinement of neural circuits, particularly in response to sensory experiences.
In mammals, BTBD3 regulates cortical neuron migration and orientation selectivity in visual and auditory systems. Its dysregulation has been implicated in neurodevelopmental disorders, such as autism spectrum disorder (ASD), and cancer. For instance, BTBD3 overexpression promotes glioblastoma cell invasion via interactions with CUL3 and ubiquitination pathways. Epigenetic studies suggest BTBD3 may modulate chromatin remodeling by recruiting histone deacetylases. Despite its established roles in neurobiology and oncology, the full spectrum of BTBD3’s molecular mechanisms and physiological targets remains under investigation, highlighting its potential as a therapeutic target or biomarker in associated diseases.
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