| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | BRD7 |
| Uniprot No | Q9NPI1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-651aa |
| 氨基酸序列 | MGKKHKKHKSDKHLYEEYVEKPLKLVLKVGGNEVTELSTGSSGHDSSLFEDKNDHDKHKDRKRKKRKKGEKQIPGEEKGRKRRRVKEDKKKRDRDRVENEAEKDLQCHAPVRLDLPPEKPLTSSLAKQEEVEQTPLQEALNQLMRQLQRKDPSAFFSFPVTDFIAPGYSMIIKHPMDFSTMKEKIKNNDYQSIEELKDNFKLMCTNAMIYNKPETIYYKAAKKLLHSGMKILSQERIQSLKQSIDFMADLQKTRKQKDGTDTSQSGEDGGCWQREREDSGDAEAHAFKSPSKENKKKDKDMLEDKFKSNNLEREQEQLDRIVKESGGKLTRRLVNSQCEFERRKPDGTTTLGLLHPVDPIVGEPGYCPVRLGMTTGRLQSGVNTLQGFKEDKRNKVTPVLYLNYGPYSSYAPHYDSTFANISKDDSDLIYSTYGEDSDLPSDFSIHEFLATCQDYPYVMADSLLDVLTKGGHSRTLQEMEMSLPEDEGHTRTLDTAKEMEITEVEPPGRLDSSTQDRLIALKAVTNFGVPVEVFDSEEAEIFQKKLDETTRLLRELQEAQNERLSTRPPPNMICLLGPSYREMHLAEQVTNNLKELAQQVTPGDIVSTYGVRKAMGISIPSPVMENNFVDLTEDTEEPKKTDVAECGPGGS |
| 分子量 | 97.13 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
1. **标题**: "BRD7 functions as a tumor suppressor in nasopharyngeal carcinoma by repressing oncogenic Wnt/β-catenin signaling"
**作者**: Peng C et al.
**摘要**: 该研究揭示BRD7在鼻咽癌中通过抑制Wnt/β-catenin信号通路发挥抑癌作用，其表达下调与肿瘤侵袭和不良预后相关。
2. **标题**: "Structural basis of bromodomain-mediated recognition of acetylated lysine in BRD7"
**作者**: Müller S et al.
**摘要**: 通过X射线晶体学解析BRD7溴结构域的三维结构，阐明其选择性结合组蛋白乙酰化修饰的分子机制。
3. **标题**: "BRD7 regulates p53-dependent senescence and autophagy in cancer cells"
**作者**: Wei Y et al.
**摘要**: 研究显示BRD7通过稳定p53蛋白诱导肿瘤细胞衰老和自噬，为BRD7靶向治疗提供分子依据。
4. **标题**: "BRD7 interacts with the SWI/SNF chromatin remodeling complex to modulate transcriptional programs"
**作者**: Dai J et al.
**摘要**: 发现BRD7作为SWI/SNF复合物的新组分，参与染色质重塑并调控细胞分化相关基因的表达。
Bromodomain-containing protein 7 (BRD7) is a member of the bromodomain protein family, characterized by conserved structural motifs that recognize acetylated lysine residues on histones, facilitating interactions with chromatin. Initially identified as a tumor suppressor, BRD7 plays critical roles in transcriptional regulation, chromatin remodeling, and cellular processes such as cell cycle control, differentiation, and apoptosis. Structurally, it contains two N-terminal bromodomains and a C-terminal domain involved in protein interactions. BRD7 interacts with components of the SWI/SNF chromatin-remodeling complex and serves as a co-regulator for transcription factors, including p53. modulating target genes linked to tumor suppression. Dysregulation of BRD7 has been implicated in cancer progression, notably in nasopharyngeal carcinoma, breast cancer, and glioblastoma, where its loss or mutation correlates with enhanced proliferation, metastasis, and genomic instability. Beyond oncology, BRD7 participates in inflammatory responses, autophagy, and metabolic regulation. Recent studies also highlight its involvement in neurodegenerative diseases and viral infection pathways. As a recombinant protein, BRD7 is widely studied to dissect its molecular mechanisms and explore therapeutic applications, including targeting bromodomains for epigenetic drug development. Its dual roles in gene regulation and disease pathways make BRD7 a key focus in understanding the intersection of epigenetics, signaling networks, and human pathologies.
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