| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | BPY2IP1 |
| Uniprot No | Q66K74 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 794-1053aa |
| 氨基酸序列 | LSDSDPVPLAPGAADSDEDTEGFGVPRHDPLPDPLKVPPPLPDPSSICMVDPEMLPPKTARQTENVSRTRKPLARPNSRAAAPKATPVAAAKTKGLAGGDRASRPLSARSEPSEKGGRAPLSRKSSTPKTATRGPSGSASSRPGVSATPPKSPVYLDLAYLPSGSSAHLVDEEFFQRVRALCYVISGQDQRKEEGMRAVLDALLASKQHWDRDLQVTLIPTFDSVAMHTWYAETHARHQALGITVLGSNSMVSMQDDAFP |
| 分子量 | 31.7kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人BPY2IP1蛋白的3篇文献概述(基于模拟研究内容)：
1. **文献名称**: *BPY2IP1 promotes testicular germ cell apoptosis via interaction with RNF4 during meiosis*
**作者**: Liang, X., et al.
**摘要**: 该研究揭示了BPY2IP1在睾丸组织中的特异性表达及其在精子减数分裂中的作用。实验表明，BPY2IP1通过与RNF4(一种泛素连接酶)相互作用，调控生精细胞凋亡，为男性不育的分子机制提供新视角。
2. **文献名称**: *Overexpression of BPY2IP1 correlates with poor prognosis in hepatocellular carcinoma*
**作者**: Xu, Y., et al.
**摘要**: 分析肝癌患者样本发现，BPY2IP1在肿瘤组织中显著高表达。体外实验证实其过表达促进肝癌细胞侵袭迁移，可能通过激活PI3K/AKT信号通路影响肿瘤进展，提示其作为肝癌预后标志物的潜力。
3. **文献名称**: *The oncogenic role of BPY2IP1 in prostate cancer through disrupting DNA repair pathways*
**作者**: Li, H., et al.
**摘要**: 研究报道BPY2IP1在前列腺癌中异常上调，并通过抑制BRCA1介导的DNA损伤修复机制促进肿瘤细胞增殖和化疗抵抗。基因沉默BPY2IP1可增强放疗敏感性，为靶向治疗提供依据。
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**注意**：上述文献为示例性内容，实际研究中需以真实发表的论文为准。若需精准检索，建议通过PubMed或Web of Science等平台输入"BPY2IP1"或"Basketball Plant Homeodomain Y-linked 2 Interacting Protein 1"获取最新文献。
Recombinant human BPY2IP1 (Basketin) protein is a product of the BPY2IP1 gene, located on the human Y chromosome (Yq11.223). This protein is predominantly expressed in testicular tissues, particularly in spermatogenic cells, suggesting a critical role in male reproduction. Structurally, BPY2IP1 contains a conserved leucine zipper domain, which may facilitate protein-protein interactions, and a coiled-coil region potentially involved in cellular processes like meiosis or sperm maturation. Functionally, it has been implicated in regulating spermatogenesis, possibly through interactions with proteins in the ubiquitin-proteasome system or mitotic spindle organization. Dysregulation of BPY2IP1 is linked to male infertility and testicular pathologies, including germ cell tumors. Recombinant BPY2IP1 is engineered using heterologous expression systems (e.g., E. coli, mammalian cells) for functional studies, antibody production, and mechanistic exploration of its reproductive and oncogenic roles. Its Y-chromosome origin and testis-specific expression also make it a candidate biomarker for male-related cancers and fertility disorders. Research on recombinant BPY2IP1 aims to clarify its molecular mechanisms and therapeutic potential in andrology and oncology.
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