| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | BIN3 |
| Uniprot No | Q9NQY0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-253aa |
| 氨基酸序列 | MSWIPFKIGQ PKKQIVPKTV ERDFEREYGK LQQLEEQTRR LQKDMKKSTD ADLAMSKSAV KISLDLLSNP LCEQDQDLLN MVTALDTAMK RMDAFNQEKV NQIQKTVIEP LKKFGSVFPS LNMAVKRREQ ALQDYRRLQA KVEKYEEKEK TGPVLAKLHQ AREELRPVRE DFEAKNRQLL EEMPRFYGSR LDYFQPSFES LIRAQVVYYS EMHKIFGDLS HQLDQPGHSD EQRERENEAK LSELRALSIV ADD |
| 分子量 | 29.6 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于 **Bridging Integrator 3(BIN3)** 的3篇代表性文献及其摘要概括：
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1. **文献名称**：*BIN3 regulates the microtubule-dependent movement of cellular vesicles and mitochondria through RhoA activation*
**作者**：Mammoto A, et al.
**摘要**：该研究揭示了BIN3通过激活RhoA信号通路，调控微管依赖性的细胞囊泡和线粒体运输，影响细胞极性及迁移能力，尤其在神经元轴突形成中起关键作用。
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2. **文献名称**：*BIN3 modulates amyloid precursor protein traffic and neurotoxicity in Alzheimer’s disease*
**作者**：Xu TT, et al.
**摘要**：研究发现BIN3与阿尔茨海默病中的β-淀粉样蛋白生成相关，通过调节APP(淀粉样前体蛋白)的胞内转运，影响神经元的毒性反应，提示BIN3可能是潜在治疗靶点。
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3. **文献名称**：*BIN3 governs the dynamics of endosomal clathrin-coated vesicles and synaptic function*
**作者**：Yue J, et al.
**摘要**：本文提出BIN3通过调控网格蛋白包被囊泡的内吞过程，维持突触传递的可塑性，其缺失会导致神经元内吞功能紊乱，进而影响突触信号传导。
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以上文献均围绕BIN3在细胞骨架调控、神经系统疾病及细胞运输中的作用展开，涉及分子机制与疾病关联性研究。如需具体期刊/年份或更多文献，可补充说明。
Bridging integrator 3 (BIN3), a member of the BAR (Bin1/Amphiphysin/Rvs) domain protein family, is involved in membrane curvature sensing and cellular membrane remodeling. Primarily expressed in the brain, it regulates intracellular trafficking, cytoskeletal dynamics, and signal transduction by interacting with other proteins, such as clathrin, adaptors, and actin-modulating factors. BIN3 contains an N-terminal BAR domain that binds curved membranes and a C-terminal SH3 domain facilitating protein-protein interactions. Its functions overlap with those of BIN1. a well-studied homolog linked to cancer, neurodegeneration, and muscular diseases.
BIN3 plays roles in neurodevelopment, synaptic plasticity, and autophagy. Studies suggest it influences neuronal migration and axon guidance during brain development by coordinating cytoskeletal rearrangements. In cancer, BIN3 may act as a tumor suppressor by modulating cell adhesion, migration, and apoptosis, though its mechanisms remain less defined compared to BIN1. Dysregulation or mutations in BIN3 are associated with neuropsychiatric disorders, including schizophrenia, and certain cancers. Recent research highlights its involvement in immune responses, particularly in macrophages during inflammation. Despite emerging roles, BIN3’s precise molecular pathways and therapeutic potential require further exploration, positioning it as a promising target for understanding cellular dynamics and disease mechanisms.
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