| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | BICD1 |
| Uniprot No | Q96G01 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-975aa |
| 氨基酸序列 | MAAEEVLQTVDHYKTEIERLTKELTETTHEKIQAAEYGLVVLEEKLTLKQQYDELEAEYDSLKQELEQLKEAFGQSFSIHRKVAEDGETREETLLQESASKEAYYLGKILEMQNELKQSRAVVTNVQAENERLTAVVQDLKENNEMVELQRIRMKDEIREYKFREARLLQDYTELEEENITLQKLVSTLKQNQVEYEGLKHEIKRFEEETVLLNSQLEDAIRLKEIAEHQLEEALETLKNEREQKNNLRKELSQYISLNDNHISISVDGLKFAEDGSEPNNDDKMNGHIHGPLVKLNGDYRTPTLRKGESLNPVSDLFSELNISEIQKLKQQLMQVEREKAILLANLQESQTQLEHTKGALTEQHERVHRLTEHVNAMRGLQSSKELKAELDGEKGRDSGEEAHDYEVDINGLEILECKYRVAVTEVIDLKAEIKALKEKYNKSVENYTDEKAKYESKIQMYDEQVTSLEKTTKESGEKMAHMEKELQKMTSIANENHSTLNTAQDELVTFSEELAQLYHHVCLCNNETPNRVMLDYYRQSRVTRSGSLKGPDDPRGLLSPRLARRGVSSPVETRTSSEPVAKESTEASKEPSPTKTPTISPVITAPPSSPVLDTSDIRKEPMNIYNLNAIIRDQIKHLQKAVDRSLQLSRQRAAARELAPMIDKDKEALMEEILKLKSLLSTKREQIATLRAVLKANKQTAEVALANLKNKYENEKAMVTETMTKLRNELKALKEDAATFSSLRAMFATRCDEYVTQLDEMQRQLAAAEDEKKTLNTLLRMAIQQKLALTQRLEDLEFDHEQSRRSKGKLGKSKIGSPKVSGEASVTVPTIDTYLLHSQGPQTPNIRVSSGTQRKRQFSPSLCDQSRPRTSGASYLQNLLRVPPDPTSTESFLLKGPPSMSEFIQGHRLSKEKRLTVAPPDCQQPAASVPPQCSQLAGRQDCPTVSPDTALPEEQPHSSSQCAPLHCLSKPPHP |
| 分子量 | 110 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
1. **"BICD1 regulates dynein-driven microtubule sliding in mammalian cells"**
*Authors: Hoogenraad CC, et al.*
摘要：探讨了BICD1如何通过与动力蛋白复合体结合调控微管滑动，揭示其在细胞分裂与胞内运输中的关键作用。
2. **"BICD1 links cargo transport to neurodevelopmental disorders"**
*Authors: Splinter D, et al.*
摘要：分析了BICD1突变如何破坏轴突运输并与智力障碍及小头畸形相关，证明其在神经元发育中的病理机制。
3. **"Structural basis of BICD1-mediated dynein-cargo adaptor assembly"**
*Authors: Gama JB, et al.*
摘要：通过冷冻电镜解析BICD1与动力蛋白的复合结构，阐明其作为适配蛋白激活货物运输的分子机制。
4. **"BICD1 recruits kinesin-1 for ER-to-Golgi transport"**
*Authors: Yu J, et al.*
摘要：揭示了BICD1协调动力蛋白与驱动蛋白双向运输的功能，强调其在膜泡转运中的双向调控作用。
(文献均为假设性示例，实际需查询数据库获取真实信息)
Bicaudal D homolog 1 (BICD1) is a member of the evolutionarily conserved Bicaudal D (BICD) protein family, known for its critical role in intracellular transport. Primarily acting as an adaptor, BICD1 facilitates dynein-dynactin motor complex-mediated retrograde transport of cargoes along microtubules, ensuring proper trafficking of vesicles, organelles, and signaling molecules. It plays a pivotal role in maintaining cellular organization, particularly in polarized cells like neurons, where it regulates axonal and dendritic transport.
BICD1 interacts with diverse cargoes, including Rab6-positive vesicles and nuclear pore components, linking them to the dynein motor. Its involvement in Golgi apparatus positioning, nuclear envelope dynamics, and cell division highlights its functional versatility. Studies also implicate BICD1 in developmental processes, such as neuronal migration and synaptic connectivity. Dysregulation of BICD1 has been associated with pathological conditions, including cancer, where altered expression may influence tumor progression via disrupted transport mechanisms.
While BICD1 shares structural homology with BICD2—a protein linked to hereditary neurodegenerative diseases—its distinct tissue-specific roles remain under investigation. Current research focuses on unraveling its regulatory mechanisms in health and disease, offering potential insights into therapeutic strategies for transport-related disorders.
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