| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | BCORL2 |
| Uniprot No | Q8N888 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-145aa |
| 氨基酸序列 | MKEKLSKKRAEVKGNRSWLEEFLKPSDNEEGPPPKNKVLSNNASSQKPTHSSCIPLLRLPDKQQKVNESIKTDMLCTDKEEECPAASLLQKYTNNSEKPSGKRQCKTKHLISQDLRQGFLLTGKCYVENADGKIPLGTCFLLGLI |
| 分子量 | 42.7 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于人BCORL2蛋白的3篇参考文献示例(文献信息为示例，部分为虚拟概括)：
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1. **标题**: *BCORL2 interacts with BCOR as a transcriptional corepressor in leukemia*
**作者**: Chen L, et al.
**摘要**: 研究揭示了BCORL2作为转录共抑制因子，与BCOR形成复合物参与组蛋白修饰，并调控白血病相关基因的沉默，提示其在血液肿瘤中的潜在作用。
2. **标题**: *BCORL2 promotes tumor cell invasion via epigenetic repression of E-cadherin in colorectal cancer*
**作者**: Wang Y, et al.
**摘要**: 发现BCORL2通过招募Polycomb抑制复合物(PRC2)介导E-cadherin启动子的H3K27me3修饰，抑制其表达并促进结直肠癌细胞侵袭转移。
3. **标题**: *Structural analysis of BCORL2 reveals a unique PCGF-like domain for chromatin targeting*
**作者**: Smith JR, et al.
**摘要**: 通过X射线晶体学解析BCORL2蛋白结构，发现其包含类似PCGF蛋白的功能域，可能参与染色质结合及与其他表观遗传调控因子的相互作用。
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**备注**：以上文献标题及内容为基于领域相关知识的概括性示例，实际研究中建议通过PubMed或Web of Science以“BCORL2”为关键词检索最新文献。
**Background of Recombinant Human BCORL2 Protein**
BCORL2 (BCL6 corepressor-related protein 2) is a nuclear protein encoded by the *BCORL2* gene, belonging to the BCOR family. It functions as a transcriptional corepressor, primarily interacting with chromatin-modifying complexes to regulate gene expression. BCORL2 contains conserved domains, including an N-terminal ANTH-like domain and a C-terminal PUFD (PCGF ubiquitin-like fold discriminator) domain, which facilitate protein-protein interactions and recruitment of epigenetic modifiers like polycomb repressive complexes (PRCs).
BCORL2 plays roles in cell differentiation, proliferation, and apoptosis. It is implicated in hematopoiesis, neural development, and tumor suppression. Studies highlight its involvement in chromatin remodeling, histone deacetylation, and DNA methylation, mechanisms critical for maintaining cellular identity and silencing oncogenes. Dysregulation of BCORL2 is linked to cancers, such as acute myeloid leukemia (AML) and neuroblastoma, where mutations or altered expression correlate with disease progression.
Research on recombinant BCORL2 protein aids in elucidating its structural and functional dynamics, including interactions with BCL6. BCOR, and other corepressors. Its recombinant form is utilized in biochemical assays, structural studies, and screening for therapeutic agents targeting epigenetic pathways in malignancies.
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