| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | BBX |
| Uniprot No | Q8WY36 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-911aa |
| 氨基酸序列 | MKGSNRNKDHSAEGEGVGKRPKRKCLQWHPLLAKKLLDFSEEEEEEDEEEDIDKVQLLGADGLEQDVGETEDDESPEQRARRPMNAFLLFCKRHRSLVRQEHPRLDNRGATKILADWWAVLDPKEKQKYTDMAKEYKDAFMKANPGYKWCPTTNKPVKSPTPTVNPRKKLWAFPSDSSRDLPSPKKAKTEEMPQLNFGMADPTQMGGLSMLLLAGEHALGTPEVSSGTCRPDVSESPELRQKSPLFQFAEISSSTSHSDASTKQCQTSALFQFAEISSNTSQLGGAEPVKRCGKSALFQLAEMCLASEGMKMEESKLIKAKESDGGRIKELEKGKEEKEIKMEKTDETRLQKEAEFEKSAKENLRDSKELRNFEALQIDDIMAIKMEDPKEIRKEELEEDHKCSHFPDFSYSASSKIIISDVPSRKDHMCHPHGIMIIEDPAALNKPEKLKKKKKKSKMDRHGNDKSTPKKTCKKRQSSESDIESVIYTIEAVAKGDWGIEKLGDTPRKKVRTSSSGKGSILDAKPPKKKVKSREKKMSKEKSSDTTKESRPPDFISISASKNISGETPEGIKAEPLTPMEDALPPSLSGQAKPEDSDCHRKIETCGSRKSERSCKGALYKTLVSEGMLTSLRANVDRGKRSSGKGNSSDHEGCWNEESWTFSQSGTSGSKKFKKTKPKEDCLLGSAKLDEEFEKKFNSLPQYSPVTFDRKCVPVPRKKKKTGNVSSEPTKTSKGSGDKWSNKQLFLDAIHPTEAIFSEDRNTMEPVHKVKNIPSIFNTPEPTTTQEPLVGSQKRKARKTKITHLVRTADGRVSPAGGTLDDKPKEQLQRSLPKATETDCNDKCSHNTEVGETRSSTPEMPAVSAFFSLAALAEVAAMENVHRGQRSTPLTHDGQPKEMPQAPVLISCADQ |
| 分子量 | 128 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | 冻干粉 |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是3篇关于人源B-box转录因子BBX(BBX)的研究文献示例(均为虚构，仅供格式参考)：
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1. **文献名称**: *BBX regulates melanoma progression through HIF-1α transcriptional activation*
**作者**: Li et al.
**摘要**: 揭示了BBX在黑色素瘤中通过直接结合缺氧诱导因子HIF-1α的启动子区，促进肿瘤血管生成和转移的分子机制。
2. **文献名称**: *Structural insights into the DNA-binding specificity of human BBX*
**作者**: Zhang & Wang
**摘要**: 利用X射线晶体学解析了BBX蛋白的HMG结构域与DNA复合物的三维结构，阐明了其识别特定AT-rich序列的分子基础。
3. **文献名称**: *BBX interacts with p53 to modulate DNA damage response*
**作者**: Gupta et al.
**摘要**: 发现BBX与肿瘤抑制蛋白p53在细胞核内物理互作，并通过调控下游靶基因表达参与DNA损伤修复和细胞周期停滞。
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注：实际文献需通过PubMed/Google Scholar检索关键词"Human BBX transcription factor"或基因编号(如HGNC:1093)，建议结合工具如Zotero管理引用。
BBX (Bobby Sox Homolog), also known as HMGBb, is a member of the high-mobility group (HMG) box protein family characterized by conserved HMG DNA-binding domains. These proteins regulate chromatin structure, transcriptional activation, and DNA repair by bending DNA and interacting with nucleosomes. Human BBX, located on chromosome 10q21.1. encodes a 396-amino acid protein containing two HMG boxes and a C-terminal acidic domain. It functions as a transcriptional co-regulator, modulating gene expression by recruiting chromatin modifiers or transcription factors.
BBX plays critical roles in cellular processes, including proliferation, differentiation, and stress responses. Studies link it to circadian rhythm regulation, stem cell maintenance, and oncogenesis. Dysregulation of BBX expression is observed in cancers (e.g., melanoma, breast cancer) and neurodegenerative disorders, suggesting its dual role as a tumor promoter or suppressor depending on context. Recent research highlights its interaction with key signaling pathways like Wnt/β-catenin and p53. As a recombinant protein, BBX is utilized in mechanistic studies to elucidate its DNA-binding specificity and regulatory networks. Its therapeutic potential, particularly in cancer and chronobiological disorders, remains an emerging focus, though precise molecular mechanisms require further characterization.
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