关键信息
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基因名
EphB6
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简介
EphB6, a kinase-defective receptor, interacts with ephrin-B1 and ephrin-B2, regulating cell adhesion and migration. It inhibits JNK activation, reduces IL-2 secretion and CD25 expression in response to ephrin-B2. EphB6 interacts with CBL, EPHB1, and FYN, highlighting its multifaceted role in cellular signaling. EphB6 Protein, Human (HEK293, His) is the recombinant human-derived EphB6 protein, expressed by HEK293 , with C-His labeled tag.
- 应用
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别名
Ephrin type-B receptor 6; HEP; Tyrosine-protein kinase-defective receptor EPH-6; EPHB8
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种属
Human
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表达系统
HEK293
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标签
C-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O15197-1
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表达区间
L32-S594
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蛋白长度
Extracellular Domain
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分子量
60-70 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
EphB6 is a member of the Eph receptor family, which plays a crucial role in various cellular processes, including cell migration, adhesion, and differentiation. Unlike other Eph receptors that are known to interact with ephrin ligands to mediate cellular signaling, EphB6 is considered a "decoy" receptor. It lacks a functional kinase domain and has been implicated in the negative regulation of signaling pathways initiated by other Eph receptors. The study of EphB6, particularly in the context of its recombinant protein form, has gained interest due to its potential roles in cancer biology and neurodevelopmental processes. Research has shown that altered expression of EphB6 is associated with several malignancies, suggesting its function as a tumor suppressor in some contexts. Furthermore, EphB6's interaction with various ligands and its impact on cell behavior could provide insights into mechanisms underlying diseases characterized by aberrant cell growth and motility. Investigating EphB6 recombinant proteins can also facilitate the development of therapeutic strategies aimed at modulating its signaling pathways. Understanding the structural and functional properties of EphB6 is essential for elucidating its role in health and disease, making it a promising target for future biomedical research.
