| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Transcription factor SOX-6 |
| Entrez GeneID | 55553; |
| WB Predicted band size | 91kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human SOX6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及SOX6抗体的文献摘要示例(注：文献为虚拟示例，仅供格式参考)：
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1. **"SOX6 regulates neuronal differentiation in murine cortical development"**
*Authors: Smith A, et al. (2021)*
摘要：本研究利用兔源抗SOX6多克隆抗体，通过免疫组化分析小鼠胚胎皮层中SOX6蛋白的表达模式，揭示其在神经元分化中的关键调控作用，抗体特异性通过Western blot验证。
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2. **"SOX6 antibody-based profiling identifies its tumor suppressor role in glioblastoma"**
*Authors: Chen L, et al. (2019)*
摘要：通过商业化小鼠单克隆SOX6抗体(货号AB123)进行免疫荧光和流式细胞术，发现SOX6在胶质母细胞瘤中低表达，其缺失促进肿瘤细胞侵袭，研究强调了抗体在临床样本检测中的可靠性。
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3. **"Chondrogenic differentiation requires SOX6-mediated collagen synthesis"**
*Authors: Tanaka K, et al. (2017)*
摘要：采用山羊多克隆SOX6抗体进行染色质免疫沉淀(ChIP)，证明SOX6直接结合COL2A1基因启动子，调控软骨细胞外基质形成，抗体特异性通过siRNA敲低实验验证。
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建议通过PubMed或Google Scholar以 **"SOX6 antibody"** 或 **"SOX6 immunohistochemistry"** 为关键词检索真实文献。实际研究中，Santa Cruz Biotechnology、Abcam等公司的抗体说明书也可能引用相关应用文献。
The SOX6 antibody is a crucial tool in studying the SOX6 protein, a member of the SOX (SRY-related HMG-box) transcription factor family. SOX6 plays pivotal roles in developmental processes, including neurogenesis, chondrogenesis, and cardiogenesis, by regulating cell differentiation, lineage commitment, and tissue maturation. It is particularly noted for its involvement in central nervous system development, where it influences neuronal subtype specification and synaptic function, as well as in skeletal development, where it interacts with SOX5 and SOX9 to drive cartilage formation. Dysregulation of SOX6 has been linked to disorders such as Parkinson’s disease, intellectual disabilities, and skeletal abnormalities.
SOX6 antibodies are widely used in research to detect and quantify SOX6 expression in cells and tissues via techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. These antibodies are essential for exploring SOX6’s functional mechanisms, interactions with co-factors (e.g., SOX5/9), and its role in disease pathways. Available as monoclonal or polyclonal variants, they are typically validated for specificity using knockout controls or siRNA-mediated knockdown. Researchers also employ SOX6 antibodies in dual-labeling studies to co-localize the protein with other markers, providing insights into its tissue-specific activity. As SOX6 gains attention in cancer biology—acting as both tumor suppressor and promoter depending on context—these antibodies remain vital for uncovering its dualistic roles in health and disease.
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