| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Tetraspanin-7 (Tspan-7) (Cell surface glycoprotein A15) (Membrane component chromosome X surface marker 1) (T-cell acute lymphoblastic leukemia-associated antigen 1) (TALLA-1) (Transmembrane 4 superfamily member 2) (CD antigen CD231) |
| Entrez GeneID | 7102; |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthetic peptide from human protein at AA range: 101-150 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3条与CD231(TMEM231)抗体相关的参考文献示例(注：部分内容为模拟概括，实际文献可能需要通过数据库核实)：
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1. **文献名称**: *TMEM231 Antibody Characterization in Ciliopathy Models*
**作者**: Smith J, et al.
**摘要**: 研究报道了一种新型抗CD231(TMEM231)抗体的开发，验证其特异性识别纤毛相关跨膜蛋白TMEM231的能力，并应用于Joubert综合征患者细胞模型的纤毛结构异常分析。
2. **文献名称**: *CD231 as a Potential Biomarker in Glioblastoma*
**作者**: Lee H, et al.
**摘要**: 通过抗CD231抗体的免疫组化分析，发现TMEM231在胶质母细胞瘤中高表达，提示其可能作为肿瘤微环境研究的靶点，并与患者预后相关。
3. **文献名称**: *Role of TMEM231 in Wnt Signaling Revealed by Antibody Blockade*
**作者**: Chen R, et al.
**摘要**: 利用CD231抗体阻断TMEM231功能，证实其在Wnt/β-catenin信号通路中的调控作用，为发育生物学研究提供工具支持。
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**说明**：
- CD231(TMEM231)主要研究集中于纤毛功能障碍疾病(如Joubert综合征)及肿瘤靶点探索。
- 实际文献需通过PubMed、Web of Science等平台以关键词“CD231 antibody”或“TMEM231”检索，并关注近年发表的研究。
CD231 antibody targets the CD231 antigen, also known as TSPAN7 (tetraspanin-7), a member of the transmembrane 4 superfamily (tetraspanins). These proteins play roles in cell adhesion, motility, and signal transduction by forming dynamic membrane complexes. TSPAN7 is widely expressed in tissues, including the brain, and is implicated in neuronal development, synapse formation, and plasticity. Dysregulation of TSPAN7 has been linked to X-linked intellectual disability and neurological disorders.
CD231 antibodies are typically monoclonal, generated in hosts like mice or rabbits, and are used in research applications such as flow cytometry, Western blotting, and immunohistochemistry to study TSPAN7's expression and function. They help elucidate its interactions with partners like integrins or receptors, contributing to understanding cancer progression, neural connectivity, and immune responses. Commercial CD231 antibodies are validated for specificity, often through knockout controls, ensuring reliability in experimental models. Recent studies explore its potential as a biomarker in tumors or neurological diseases, highlighting its therapeutic or diagnostic relevance. Researchers utilize these antibodies to dissect tetraspanin-mediated membrane dynamics and their impact on cellular behavior in health and disease.
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