| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Hyaluronan mediated motility receptor (Intracellular hyaluronic acid-binding protein) (Receptor for hyaluronan-mediated motility) (CD antigen CD168) |
| Entrez GeneID | 3161; |
| WB Predicted band size | 84kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide from human protein at AA range: 280-340 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇与CD168(RHAMM)抗体相关的示例文献摘要(注：文献为虚拟示例，仅供格式参考)：
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1. **文献名称**: *CD168 Expression Predicts Metastatic Potential in Breast Cancer*
**作者**: Smith A, et al.
**摘要**: 本研究利用抗CD168单克隆抗体进行免疫组化分析，发现CD168在乳腺癌组织中的高表达与淋巴结转移和不良预后显著相关，提示其作为转移标志物的潜在价值。
2. **文献名称**: *RHAMM-specific Antibody Inhibits Leukemia Cell Migration In Vitro*
**作者**: Lee J, et al.
**摘要**: 通过抗CD168抗体阻断RHAMM受体功能，显著抑制了急性髓系白血病细胞的透明质酸介导的迁移能力，为靶向CD168的抗体治疗提供了实验依据。
3. **文献名称**: *CD168 Antibody-based CAR-T Therapy in Solid Tumors*
**作者**: Chen X, et al.
**摘要**: 研究构建了靶向CD168的CAR-T细胞，并证明其在体外和动物模型中能有效杀伤CD168高表达的卵巢癌细胞，提示该抗体在免疫治疗中的应用潜力。
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如需真实文献，建议通过PubMed或Google Scholar搜索关键词“CD168 antibody”或“RHAMM antibody”获取最新研究。
CD168 antibody targets the CD168 antigen, also known as Receptor for Hyaluronan-Mediated Motility (RHAMM), a cell surface glycoprotein encoded by the *HMMR* gene. RHAMM/CD168 interacts with hyaluronan to regulate cell motility, proliferation, and intracellular signaling, particularly through pathways involving ERK and FAK. It is expressed in various tissues, including activated immune cells, stem cells, and cancer cells.
CD168 gained attention due to its overexpression in multiple cancers (e.g., breast, prostate, colorectal) where it promotes tumor progression, metastasis, and poor prognosis. Its role in cancer cell migration and invasion makes it a potential therapeutic target. CD168 antibodies are widely used in research to detect RHAMM expression via techniques like immunohistochemistry, flow cytometry, and Western blot. They help elucidate RHAMM's biological functions, including its dual roles in physiological processes (wound healing) and pathological states (cancer metastasis).
However, challenges remain in antibody specificity due to RHAMM isoforms and intracellular vs. surface localization. Despite this, CD168 antibodies remain critical tools for studying RHAMM's oncogenic mechanisms and its potential as a diagnostic biomarker or immunotherapeutic target in precision medicine.
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