| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | IL17RC |
| Uniprot No | Q8NAC3 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-791aa |
| 氨基酸序列 | MPVPWFLLSLALGRSPVVLSLERLVGPQDATHCSPVSLEPWGDEERLRVQFLAQQSLSLAPVTAATARTALSGLSGADGRREERGRGKSWVCLSLGGSGNTEPQKKGLSCRLWDSDILCLPGDIVPAPGPVLAPTHLQTELVLRCQKETDCDLCLRVAVHLAVHGHWEEPEDEEKFGGAADSGVEEPRNASLQAQVVLSFQAYPTARCVLLEVQVPAALVQFGQSVGSVVYDCFEAALGSEVRIWSYTQPRYEKELNHTQQLPDCRGLEVWNSIPSCWALPWLNVSADGDNVHLVLNVSEEQHFGLSLYWNQVQGPPKPRWHKNLTGPQIITLNHTDLVPCLCIQVWPLEPDSVRTNICPFREDPRAHQNLWQAARLQLLTLQSWLLDAPCSLPAEAALCWRAPGGDPCQPLVPPLSWENVTVDKVLEFPLLKGHPNLCVQVNSSEKLQLQECLWADSLGPLKDDVLLLETRGPQDNRSLCALEPSGCTSLPSKASTRAARLGEYLLQDLQSGQCLQLWDDDLGALWACPMDKYIHKRWALVWLACLLFAAALSLILLLKKDHAKGWLRLLKQDVRSGAAARGRAALLLYSADDSGFERLVGALASALCQLPLRVAVDLWSRRELSAQGPVAWFHAQRRQTLQEGGVVVLLFSPGAVALCSEWLQDGVSGPGAHGPHDAFRASLSCVLPDFLQGRAPGSYVGACFDRLLHPDAVPALFRTVPVFTLPSQLPDFLGALQQPRAPRSGRLQERAEQVSRALQPALDSYFHPPGTPAPGRGVGPGAGPGAGDGT |
| 预测分子量 | kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于IL17RC重组蛋白的3篇参考文献及简要摘要：
1. **《IL-17 receptor C signaling in inflammation and autoimmune disease》**
- 作者：Gaffen, S.L. et al.
- 摘要：该文献探讨了IL-17RC受体在炎症信号通路中的作用，通过重组蛋白实验揭示了其与IL-17A和IL-17F结合的分子机制，并证明其在银屑病和类风湿性关节炎中的关键调控功能。
2. **《Structural characterization of recombinant IL17RC extracellular domain and its ligand interactions》**
- 作者：Hu, Y. et al.
- 摘要：研究通过表达并纯化IL17RC重组胞外结构域蛋白，利用X射线晶体学解析其三维结构，揭示了IL17RC与IL-17配体结合的特异性位点，为靶向药物设计提供结构基础。
3. **《IL17RC promotes IL-17A-mediated neutrophil recruitment in acute lung injury》**
- 作者：Chen, K. et al.
- 摘要：通过构建IL17RC重组蛋白突变体，研究证明IL17RC在急性肺损伤模型中通过增强IL-17A信号通路驱动中性粒细胞浸润，提示其作为治疗炎症性肺病的潜在靶点。
**Background of IL17RC Recombinant Protein**
Interleukin-17 receptor C (IL17RC) is a key component of the IL-17 receptor family, which mediates signaling of pro-inflammatory cytokines IL-17A and IL-17F. These cytokines play critical roles in host defense, autoimmune diseases, and chronic inflammation. IL17RC typically forms a heterodimeric receptor complex with IL17RA, enabling ligand binding and downstream signaling via pathways like NF-κB and MAPK. Dysregulation of IL-17/IL17RC signaling is implicated in pathologies such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease, making it a therapeutic target.
Recombinant IL17RC protein is engineered *in vitro* using expression systems like mammalian cells (e.g., HEK293 or CHO) to ensure proper post-translational modifications, such as glycosylation, which are crucial for ligand binding and receptor function. The protein often includes the extracellular domain (ECD) to facilitate interaction studies with IL-17 cytokines or inhibitors. Tags like Fc or His are added for purification and detection.
In research, recombinant IL17RC is used to study IL-17 signaling mechanisms, screen potential inhibitors, and develop biologics targeting IL-17-driven diseases. It also serves as a critical tool for structural studies (e.g., crystallography) to map binding interfaces or engineer mutants for functional analysis. Additionally, it aids in antibody development and diagnostic assays.
Overall, IL17RC recombinant protein bridges basic research and therapeutic innovation, offering insights into inflammation biology and accelerating drug discovery for immune-mediated disorders.
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