关键信息
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基因名
EPHA10
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简介
The EPHA10 protein is a receptor for members of the ephrin A family and specifically interacts with EFNA3, EFNA4, and EFNA5. EPHA10 belongs to the Eph receptor tyrosine kinase family, mediates cellular responses to ephrin ligands, and affects processes such as cell adhesion, migration, and developmental patterns. EPHA10 Protein, Human (HEK293, His) is the recombinant human-derived EPHA10 protein, expressed by HEK293 , with C-His labeled tag.
- 应用
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别名
EphA10; FLJ16103; FLJ33655; MGC43817
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种属
Human
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表达系统
HEK293
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标签
C-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q5JZY3-1
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表达区间
E34-A565
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蛋白长度
Extracellular Domain
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分子量
60-70 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
EPHA10 is a member of the Eph receptor tyrosine kinases, which play significant roles in various biological processes, including cell adhesion, migration, and differentiation. These receptors are crucial for the development of the nervous system and the formation of blood vessels. Due to their involvement in tumorigenesis and metastasis, EPHA10 has garnered attention as a potential target for cancer therapy. Research has shown that aberrations in EPHA10 expression are associated with various cancers, including breast, prostate, and colorectal cancers. Furthermore, studies indicate that EPHA10 can modulate tumor growth and invasion, making it a promising candidate for therapeutic intervention. The generation of recombinant EPHA10 protein is essential for understanding its structure-function relationship, enabling researchers to investigate its signaling pathways and interaction with ligands in detail. Additionally, recombinant EPHA10 can be utilized in drug screening assays and as a basis for developing novel therapeutic agents. Given the urgent need for targeted cancer therapies, ongoing studies aim to elucidate the precise mechanisms by which EPHA10 contributes to tumor biology, ultimately facilitating the identification of new strategies for managing malignancies associated with this receptor.
