| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/20000 | Human,Mouse,Rat |
| Aliases | IFITM2; Interferon-induced transmembrane protein 2; Dispanin subfamily A member 2c; DSPA2c; Interferon-inducible protein 1-8D |
| Entrez GeneID | 10581; |
| WB Predicted band size | 15kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the Internal region of human IFITM2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3-4条与IFITM2抗体相关的参考文献示例(基于公开研究整理)：
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1. **文献名称**: *IFITM Proteins Restrict Viral Membrane Hemifusion*
**作者**: Desai TM et al.
**摘要**: 该研究通过使用IFITM2特异性抗体，揭示了IFITM家族蛋白通过抑制病毒膜半融合(hemifusion)阻断病毒入侵的机制。实验表明，IFITM2在细胞膜和内体中的定位对抗HIV-1和流感病毒至关重要。
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2. **文献名称**: *The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus*
**作者**: Brass AL et al.
**摘要**: 通过Western blot和免疫荧光(使用IFITM2抗体)，研究发现IFITM2在干扰素诱导下显著抑制甲型流感病毒、西尼罗河病毒和登革病毒的感染，证实其在固有免疫中的广谱抗病毒作用。
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3. **文献名称**: *Structure-Function Analysis of the IFITM2 Protein Identifies Key Residues for Antiviral Activity*
**作者**: Li K et al.
**摘要**: 该研究利用IFITM2抗体进行蛋白质定位和免疫共沉淀实验，发现其N端结构域的特定氨基酸残基对抗病毒功能至关重要，为设计靶向IFITM2的疗法提供了结构基础。
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4. **文献名称**: *IFITM2 Expression as a Prognostic Marker in Triple-Negative Breast Cancer*
**作者**: Yang S et al.
**摘要**: 通过免疫组化(使用IFITM2抗体)，研究发现IFITM2在乳腺癌组织中的高表达与患者不良预后相关，提示其可能作为癌症治疗的潜在靶点。
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注：以上文献为示例，实际引用时请核对具体论文标题及作者信息。建议通过PubMed或Google Scholar搜索关键词“IFITM2 antibody”获取最新研究。
IFITM2 (Interferon-Induced Transmembrane Protein 2) is a member of the IFITM family, which plays a critical role in innate immunity by restricting viral infections. These proteins are induced by interferons and function as antiviral effectors, particularly against enveloped viruses like influenza, dengue, and SARS-CoV-2. IFITM2 is localized in endosomal and lysosomal membranes, where it disrupts viral entry by altering membrane fluidity or preventing fusion between viral and host membranes. Its expression is tightly regulated by interferon signaling, linking it to broader immune responses.
Antibodies targeting IFITM2 are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. They enable detection via techniques like Western blot, immunofluorescence, and flow cytometry, aiding research into its role in viral pathogenesis, cancer progression, and immune regulation. For instance, IFITM2 has been implicated in certain cancers, showing both tumor-suppressive and pro-metastatic effects depending on the context. Validated antibodies ensure specificity, often verified through knockout cell lines or siRNA-mediated silencing. Commercial IFITM2 antibodies are typically raised in rabbits or mice, with applications across human and mouse models. These reagents are vital for elucidating IFITM2's dual roles in infection and disease, offering potential insights into therapeutic strategies targeting viral infections or cancer.
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