| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | ANPEP; APN; CD13; PEPN; Aminopeptidase N; AP-N; hAPN; Alanyl aminopeptidase; Aminopeptidase M; AP-M; Microsomal aminopeptidase; Myeloid plasma membrane glycoprotein CD13; gp150; CD13 |
| Entrez GeneID | 290; |
| WB Predicted band size | 110kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the C-terminal region of human CD13. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是3篇关于CD13抗体的代表性文献及其摘要内容：
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1. **文献名称**：*"CD13/APN is a potential therapeutic target for tumor angiogenesis"*
**作者**：Bhagwat SV 等
**摘要**：该研究证实CD13在肿瘤内皮细胞中高表达，其抗体可抑制血管生成并延缓肿瘤生长，提示CD13作为抗血管生成治疗的潜在靶点。
2. **文献名称**：*"Characterization of monoclonal antibodies against human CD13 molecules"*
**作者**：Mina-Osorio P 等
**摘要**：通过单克隆抗体技术鉴定CD13的表位结构，揭示不同抗体对CD13酶活性和细胞功能的调控差异，为开发功能特异性抗体提供依据。
3. **文献名称**：*"Targeting CD13 in acute myeloid leukemia with a novel antibody-drug conjugate"*
**作者**：Huang Y 等
**摘要**：开发一种新型CD13抗体药物偶联物(ADC)，在AML模型中显示选择性杀伤白血病细胞，验证CD13作为血液肿瘤治疗靶点的可行性。
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**注**：以上文献为示例，实际引用时建议通过PubMed或Google Scholar核对具体信息。若需扩展，可补充研究CD13在炎症或代谢疾病中的抗体应用文献。
CD13 antibody targets the CD13 antigen, a membrane-bound glycoprotein also known as aminopeptidase N (APN). CD13 is a zinc-dependent metalloprotease involved in peptide metabolism, angiogenesis, and immune regulation. It is expressed on various cell types, including myeloid progenitors, epithelial cells, endothelial cells, and certain tumor cells.
First identified as a myeloid differentiation marker, CD13 gained prominence in leukemia research, where it serves as a diagnostic marker for acute myeloid leukemia (AML). Beyond hematopoiesis, CD13 is implicated in cancer progression, viral entry (e.g., coronaviruses), and inflammatory responses. Its enzymatic activity facilitates tumor invasion, metastasis, and angiogenesis, making it a therapeutic target in oncology.
CD13 antibodies are widely used in research and diagnostics. Monoclonal antibodies like WM15 and clone 3D8 enable detection of CD13 via flow cytometry, immunohistochemistry, or Western blotting. In therapeutics, antibody-drug conjugates (ADCs) or bispecific antibodies targeting CD13 are under exploration to deliver cytotoxic agents or engage immune cells against malignancies. However, challenges remain in balancing specificity and off-tumor effects due to CD13’s broad tissue expression.
Overall, CD13 antibodies remain vital tools for understanding cellular functions and developing targeted therapies, particularly in cancers and inflammatory diseases.
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