| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000 | Human,Mouse,Rat |
| Aliases | ZNF608; KIAA1281; Zinc finger protein 608; Renal carcinoma antigen NY-REN-36 |
| Entrez GeneID | 57507; |
| WB Predicted band size | 160kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from the C-terminal region of human ZNF608. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于ZNF608抗体的模拟参考文献示例(内容为虚构，仅作格式参考)：
1. **文献名称**：*ZNF608 regulates skeletal muscle differentiation through transcriptional repression of myogenic inhibitors*
**作者**：Smith A, et al.
**摘要**：本研究利用ZNF608抗体进行免疫沉淀和染色质分析，发现ZNF608通过抑制MyoD拮抗因子(如MEF2C)的转录，促进成肌细胞分化和骨骼肌发育。
2. **文献名称**：*ZNF608 expression is elevated in rhabdomyosarcoma and correlates with poor prognosis*
**作者**：Chen L, et al.
**摘要**：通过ZNF608抗体的免疫组化分析，发现横纹肌肉瘤中ZNF608蛋白高表达，其水平与肿瘤侵袭性和患者生存率下降显著相关。
3. **文献名称**：*CRISPR screening identifies ZNF608 as a regulator of cell cycle exit in fibroblasts*
**作者**：Wang Y, et al.
**摘要**：结合CRISPR筛选和ZNF608抗体的Western blot验证，揭示ZNF608通过调控p21和Cyclin D1表达，影响成纤维细胞的细胞周期退出和组织修复。
4. **文献名称**：*ZNF608 interacts with HDAC4 to modulate cardiac hypertrophy signaling*
**作者**：Kim J, et al.
**摘要**：使用ZNF608抗体进行共免疫沉淀实验，发现ZNF608与组蛋白去乙酰化酶HDAC4相互作用，共同调节病理性心肌肥厚的信号通路。
**注意**：以上为模拟内容，实际文献需通过PubMed、Google Scholar等平台检索(关键词：ZNF608 antibody, zinc finger protein 608)。
The ZNF608 antibody is a tool used to detect Zinc Finger Protein 608 (ZNF608), a member of the zinc finger protein family characterized by conserved C2H2-type zinc finger domains. ZNF608 is implicated in transcriptional regulation, though its precise biological functions remain under investigation. Studies suggest it plays roles in developmental processes, including limb formation and neural development, potentially by modulating gene expression networks or chromatin remodeling. Dysregulation of ZNF608 has been linked to human diseases, such as craniosynostosis (premature skull suture fusion) and certain cancers, where its aberrant expression may influence cell proliferation or differentiation pathways.
The antibody is widely utilized in research applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study ZNF608's expression patterns, subcellular localization, and interactions. Its specificity is critical for distinguishing ZNF608 from homologous proteins, requiring validation via knockout controls or epitope mapping. Recent findings highlight ZNF608's involvement in regulating signaling pathways like SHH (Sonic Hedgehog) or Wnt, emphasizing its potential as a biomarker or therapeutic target. However, functional studies remain limited, underscoring the need for further exploration of its molecular mechanisms and disease relevance.
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