| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/20000 | Human,Mouse,Rat |
| Aliases | OR1D5; Olfactory receptor 1D5; Olfactory receptor 17-31; OR17-31; OR1D4; Olfactory receptor 1D4; Olfactory receptor 17-30; OR17-30 |
| Entrez GeneID | 8386; |
| WB Predicted band size | 38kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the Internal region of human Olfactory receptor 1D4/1D5. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于Olfactory receptor 1D4/1D5抗体的模拟参考文献示例(仅供学术写作参考，实际文献需通过数据库检索)：
1. **文献名称**: *"Expression and functional characterization of olfactory receptor 1D4 in human testicular tissues"*
**作者**: Fukuda N, et al.
**摘要**: 本研究利用特异性抗体(OR1D4/1D5)通过免疫组化和Western blot技术，首次证实OR1D4在人类睾丸组织中的表达，并揭示其在精子发生中的潜在调控作用。
2. **文献名称**: *"Antibody-based detection of olfactory receptor 1D5 in cancer cell lines"*
**作者**: Spehr M, et al.
**摘要**: 通过开发高特异性OR1D5抗体，研究发现该受体在乳腺癌细胞系中异常表达，并可能通过激活cAMP信号通路促进肿瘤细胞迁移。
3. **文献名称**: *"Olfactory receptor 1D4 mediates sperm chemotaxis via antibody-blocking assays"*
**作者**: Zhang X, et al.
**摘要**: 使用OR1D4抗体阻断实验，证明该受体在精子趋化性中起关键作用，为生殖生物学研究提供了新的分子靶点。
4. **文献名称**: *"Cross-reactivity analysis of anti-OR1D4/1D5 antibodies in murine models"*
**作者**: Plessis S, et al.
**摘要**: 系统性评估OR1D4/1D5抗体的物种交叉反应性，确认其在啮齿类动物模型中的适用性，并优化了抗体在组织切片中的染色条件。
**注**：以上文献为模拟示例，实际引用需通过PubMed、Web of Science或抗体供应商(如Abcam、Thermo Fisher)提供的参考文献链接获取真实数据。
Olfactory receptors (ORs) are a large family of G protein-coupled receptors (GPCRs) primarily involved in detecting odorants in the nasal epithelium. Among them, OR1D4 (also known as OR1D5 or OR1D2 in some species) is a well-studied member, though its exact functional role remains partially elusive. Unlike canonical olfactory receptors, OR1D4/1D5 has been detected in non-olfactory tissues, including the prostate, testes, and certain cancer cells, suggesting potential roles beyond smell, such as cellular signaling or disease pathways.
Antibodies targeting OR1D4/1D5 are critical tools for investigating its expression, localization, and function. These antibodies are typically developed using immunogenic peptide sequences derived from conserved regions of the receptor’s extracellular or intracellular domains. They enable applications like Western blotting, immunohistochemistry, and flow cytometry to study tissue-specific expression patterns or pathological associations. For example, OR1D4/1D5 upregulation in prostate cancer has spurred interest in its diagnostic or therapeutic potential.
However, challenges persist due to ORs’ structural homology and low abundance in non-olfactory tissues, requiring rigorous validation of antibody specificity. Research using these antibodies continues to explore OR1D4/1D5’s physiological roles, including possible involvement in chemotaxis, hormone regulation, or tumor progression, highlighting its dual identity as both a chemosensor and a multifaceted signaling molecule.
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