关键信息
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基因名
CXCR2
- 应用
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别名
CD182; CDw128b; IL8R-B; IL8-RB; CMKAR2; CXCR2; IL8R2; C-X-C chemokine receptor type 2; GRO/MGSA receptor; High affinity interleukin-8 receptor B
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种属
Human
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表达系统
E. coli
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标签
N- His & GST
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纯度
Greater than 85% as determined by SDS-PAGE.
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蛋白编号
P25025
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表达区间
Met1~Leu57
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蛋白长度
Partial
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分子量
37kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
CXCR2, a member of the CXC chemokine receptor family, is a G-protein coupled receptor that plays a pivotal role in regulating immune responses, inflammation, and hematopoiesis by mediating the recruitment of neutrophils to sites of infection or injury. Its ligands, including IL-8 and other CXC chemokines, bind to CXCR2 and activate downstream signaling pathways that influence various cellular functions such as migration, survival, and activation of immune cells. Dysregulation of CXCR2 signaling has been implicated in several pathological conditions, including cancer progression, chronic inflammatory diseases, and respiratory disorders. As a result, CXCR2 has emerged as a potential therapeutic target. Researchers have been increasingly focused on generating CXCR2 recombinant proteins to study its structure-function relationships, binding properties, and interactions with specific ligands. The production of these recombinant proteins allows for detailed functional analyses and the development of CXCR2 antagonists or agonists. Additionally, understanding the receptor’s signaling mechanisms and its role in disease contexts can provide insights for novel therapeutic strategies, thereby highlighting the importance of CXCR2 in both basic research and clinical applications.
