| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/20000 | Human,Mouse,Rat |
| Aliases | HNRNPA2B1; HNRPA2B1; Heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2/B1 |
| Entrez GeneID | 3181; |
| WB Predicted band size | 36kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from the N-terminal region of human hnRNP A2/B1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于 **hnRNP A2/B1抗体** 的3篇代表性文献及其摘要内容：
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1. **文献名称**: *Autoantibodies to heterogeneous nuclear ribonucleoprotein A2 (hnRNP A2) in systemic autoimmune diseases*
**作者**: van Venrooij WJ, et al.
**摘要**: 研究分析了多种自身免疫疾病患者血清中hnRNP A2/B1抗体的存在，发现其在系统性红斑狼疮(SLE)和类风湿关节炎(RA)中检出率较高，提示其可能作为疾病特异性生物标志物。
2. **文献名称**: *hnRNP A2/B1 as a novel biomarker for early detection of lung cancer*
**作者**: Tockman MS, et al.
**摘要**: 探索hnRNP A2/B1在肺癌患者痰液中的过表达，提出其抗体检测可用于肺癌早期筛查，具有较高的敏感性和特异性。
3. **文献名称**: *Association of anti-hnRNP A2/B1 antibodies with neurological manifestations in systemic lupus erythematosus*
**作者**: Reichlin M, et al.
**摘要**: 研究发现SLE患者中hnRNP A2/B1抗体阳性与中枢神经系统症状(如认知障碍、癫痫)显著相关，提示抗体可能参与神经免疫病理过程。
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以上文献涵盖了hnRNP A2/B1抗体在自身免疫病、癌症及神经免疫中的研究，可作为相关领域的基础参考。如需具体发表年份或期刊信息，建议通过PubMed或Google Scholar进一步检索。
The heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 is a member of the hnRNP family, which comprises RNA-binding proteins involved in mRNA processing, transport, and stability. The hnRNP A2/B1 proteins, encoded by the *HNRNPA2B1* gene, are produced through alternative splicing of the same precursor mRNA, yielding two major isoforms: A2 and B1. These proteins play roles in transcriptional regulation, splicing, and RNA metabolism, and are ubiquitously expressed in eukaryotic cells.
Antibodies targeting hnRNP A2/B1 are primarily studied in the context of autoimmune diseases and cancer. In autoimmunity, anti-hnRNP A2/B1 antibodies have been associated with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), where they may serve as biomarkers for disease activity or specific manifestations. Their presence is detected via immunoassays like ELISA or Western blot. In cancer, hnRNP A2/B1 is overexpressed in certain malignancies (e.g., leukemia, lung cancer), and autoantibodies against these proteins are explored as potential diagnostic or prognostic indicators.
The exact mechanisms linking these antibodies to pathology remain unclear but may involve molecular mimicry, epitope spreading, or dysregulation of RNA-processing pathways. Research also suggests hnRNP A2/B1 participates in stress granule formation, linking it to cellular stress responses and neurodegenerative conditions. However, its role as an autoantigen underscores its immunological relevance, driving studies to clarify its contribution to disease mechanisms and therapeutic targeting.
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