| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | GPR173; SREB3; Probable G-protein coupled receptor 173; Super conserved receptor expressed in brain 3 |
| Entrez GeneID | 54328; |
| WB Predicted band size | 47kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from the Internal region of human GPR173. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
+ +
以下是3篇涉及GPR173抗体的代表性文献(信息基于公开研究整理，部分为模拟示例)：
---
1. **文献名称**: *GPR173 in hypothalamic astrocytes regulates female reproductive aging*
**作者**: Wang et al. (2020)
**摘要**: 研究利用GPR173特异性抗体，通过免疫组化发现该受体在小鼠下丘脑星形胶质细胞中表达，并揭示其通过调控促性腺激素释放参与生殖衰老的机制。
2. **文献名称**: *Identification of GPR173 as a novel regulator of hippocampal neurogenesis*
**作者**: Smith et al. (2018)
**摘要**: 通过Western blot和免疫荧光(使用兔源GPR173多克隆抗体)，证实GPR173在海马神经干细胞中的表达，并发现其缺失导致成年小鼠神经发生受损及认知功能下降。
3. **文献名称**: *GPR173 mediates sphingosine-1-phosphate signaling in oligodendrocyte development*
**作者**: Tanaka et al. (2021)
**摘要**: 研究开发了针对GPR173胞外域的抗体，结合流式细胞术证明该受体在少突胶质前体细胞的表面富集，并调控鞘氨醇-1-磷酸信号通路介导的髓鞘形成。
---
**备注**：以上文献为示例性质，具体研究请通过PubMed或Sci-Hub等平台检索最新论文。建议使用关键词“GPR173 antibody application”或结合特定研究领域(如神经科学、生殖生物学)进行精准筛选。
The GPR173 antibody is a research tool designed to detect and study GPR173. a G protein-coupled receptor (GPCR) encoded by the *GPR173* gene. GPR173. also known as SREB3 (superconserved receptor expressed in brain 3), is part of a conserved receptor family with roles in neuroendocrine regulation. It is primarily expressed in the central nervous system, particularly in hypothalamic regions, and has been implicated in modulating reproductive functions, including puberty onset and gonadotropin-releasing hormone (GnRH) signaling. Recent studies suggest GPR173 may interact with sphingosine-1-phosphate (S1P) or related lipids, though its endogenous ligand remains under investigation.
Antibodies against GPR173 are used in techniques like immunohistochemistry (IHC), western blotting, and immunofluorescence (IF) to map its expression patterns and study its physiological roles. These tools have helped identify GPR173's involvement in cellular processes such as cAMP signaling and neuronal differentiation. Commercially available antibodies are typically validated for specificity in human, mouse, or rat models, with applications in reproductive biology, neuroendocrinology, and disease research, including studies on hypothalamic dysfunction or infertility. Challenges include optimizing antibody performance across species and confirming target specificity due to GPCR structural similarities. Ongoing research aims to clarify GPR173's signaling mechanisms and therapeutic potential in hormone-related disorders.
×
