| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/200-1/1000 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000 | Human,Mouse,Rat |
| Aliases | O3FAR1; GPR120; GPR129; PGR4; Omega-3 fatty acid receptor 1; G-protein coupled receptor 120; G-protein coupled receptor 129; G-protein coupled receptor GT01; G-protein coupled receptor PGR4 |
| Entrez GeneID | 338557; |
| WB Predicted band size | 38kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from the Internal region of human GPR120. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于GPR120抗体的3篇参考文献示例(注：文献信息为模拟示例，建议通过学术数据库查询真实文献)：
1. **文献名称**: *"Development and characterization of a selective GPR120 antibody for metabolic studies"*
**作者**: Smith A, et al.
**摘要**: 该研究报道了一种新型GPR120特异性抗体的开发，验证了其在人脂肪组织和巨噬细胞中的特异性结合能力，并证实其在研究GPR120介导的胰岛素敏感性调节中的作用。
2. **文献名称**: *"GPR120 antibody-based targeting of omega-3 fatty acid signaling in inflammation"*
**作者**: Tanaka K, et al.
**摘要**: 利用GPR120抗体阻断实验，揭示了ω-3脂肪酸通过GPR120受体抑制炎症反应的分子机制，为抗炎治疗提供了潜在靶点。
3. **文献名称**: *"Validation of GPR120 antibody for immunohistochemical analysis in murine tissues"*
**作者**: Lee S, et al.
**摘要**: 通过免疫组化和Western blot验证了GPR120抗体在小鼠肠道和肝脏组织中的特异性，发现其可用于追踪GPR120在脂代谢相关器官中的表达分布。
如需实际文献，建议检索PubMed或Web of Science并筛选关键词“GPR120 antibody”或“FFAR4 antibody”。
GPR120 (G protein-coupled receptor 120), also known as FFAR4 (free fatty acid receptor 4), is a cell membrane receptor belonging to the G protein-coupled receptor (GPCR) family. It is activated by long-chain free fatty acids, particularly omega-3 fatty acids, and plays a critical role in regulating metabolic homeostasis, inflammation, and appetite. Primarily expressed in adipose tissue, the gastrointestinal tract, and immune cells, GPR120 is involved in insulin sensitization, glucagon-like peptide-1 (GLP-1) secretion, and anti-inflammatory signaling pathways, such as the inhibition of NF-κB. Dysregulation of GPR120 has been linked to obesity, insulin resistance, and metabolic disorders, making it a therapeutic target for metabolic diseases.
GPR120 antibodies are essential tools for studying the receptor’s expression, localization, and function in various tissues. They enable detection of GPR120 in immunoassays (e.g., Western blot, immunohistochemistry) and aid in elucidating its role in signaling pathways, such as β-arrestin recruitment or AMPK activation. Some antibodies are also designed to modulate receptor activity, either as agonists or antagonists, to explore therapeutic potential. Challenges in antibody development include ensuring specificity due to structural similarities among GPCRs and optimizing cross-reactivity across species in preclinical models. Research using GPR120 antibodies continues to advance understanding of its dual role in metabolism and inflammation, supporting drug discovery efforts for diabetes, obesity, and inflammatory diseases.
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