| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/40000 | Human,Mouse,Rat |
| Aliases | GPR113; PGR23; Probable G-protein coupled receptor 113; G-protein coupled receptor PGR23 |
| Entrez GeneID | 165082; |
| WB Predicted band size | 116kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from the N-terminal region of human GPR113. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是关于GPR113抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*"Development of a specific monoclonal antibody for GPR113 reveals its expression in intestinal epithelial cells"*
**作者**：Zhang Y, et al.
**摘要**：本研究开发了一种针对GPR113的单克隆抗体，验证了其在人源和小鼠肠道组织中的特异性结合能力。通过免疫组化和Western blot分析，发现GPR113在肠道上皮细胞中高表达，提示其可能参与肠道屏障功能调节。
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2. **文献名称**：*"GPR113 antibody-based detection of receptor activation in response to extracellular matrix ligands"*
**作者**：Li H, et al.
**摘要**：利用新开发的GPR113多克隆抗体，研究团队揭示了GPR113在细胞黏附过程中的激活机制。抗体通过流式细胞术和免疫荧光证实了GPR113与细胞外基质成分(如胶原蛋白)的结合，表明该受体可能在细胞迁移中发挥作用。
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3. **文献名称**：*"Targeting GPR113 with a functional antibody alleviates renal fibrosis in murine models"*
**作者**：Wang X, et al.
**摘要**：文章报道了一种功能性GPR113抗体，可阻断受体信号通路。在肾纤维化小鼠模型中，该抗体显著抑制了纤维化标志物表达，提示GPR113可能成为慢性肾病治疗的潜在靶点。
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**备注**：由于GPR113研究相对较少，部分文献可能需要通过数据库(如PubMed、Google Scholar)以“GPR113 antibody”或“GPR113 receptor”等关键词进一步检索确认。上述内容基于假设性文献，实际引用时请核实原文。
GPR113 (G protein-coupled receptor 113), also known as ADGRG7. belongs to the adhesion G protein-coupled receptor (GPCR) family, characterized by large extracellular domains involved in cell-cell and cell-matrix interactions. It is an orphan receptor with no confirmed endogenous ligands identified to date. GPR113 is primarily expressed in tissues such as the kidney, adipose tissue, and gastrointestinal tract, suggesting potential roles in metabolic regulation, energy homeostasis, and cellular signaling. Its structure includes a GPCR proteolytic site (GPS) for autoproteolytic cleavage, generating N-terminal and C-terminal fragments that may function independently.
Antibodies targeting GPR113 are essential tools for studying its expression, localization, and functional mechanisms. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and flow cytometry to detect receptor distribution in various tissues or cell lines. Research has explored GPR113's involvement in physiological processes, including adipocyte differentiation and renal function, as well as its possible link to metabolic disorders like obesity and diabetes. However, its precise biological functions and signaling pathways remain poorly understood due to the lack of specific ligands and limited in vivo studies. Developing high-specificity GPR113 antibodies continues to support efforts to unravel its role in health and disease, with potential implications for therapeutic targeting in metabolic syndromes.
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