| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/40000 | Human,Mouse,Rat |
| Aliases | ZDHHC9; CXorf11; ZDHHC10; ZNF379; ZNF380; CGI-89; Palmitoyltransferase ZDHHC9; Zinc finger DHHC domain-containing protein 9; DHHC-9; DHHC9; Zinc finger protein 379; Zinc finger protein 380 |
| Entrez GeneID | 51114; |
| WB Predicted band size | 41kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized peptide derived from the C-terminal region of human DHHC-9. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
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以下是为您模拟生成的3篇关于DHHC-9抗体的参考文献示例(注：文献信息为虚构，仅供格式参考，建议通过PubMed/Google Scholar查询真实文献)：
1. **"DHHC9-mediated palmitoylation regulates synaptic plasticity in mouse models of intellectual disability"**
- 作者：Li X, et al.
- 摘要：研究通过DHHC-9特异性抗体发现其在小鼠海马神经元中的棕榈酰化酶活性缺失会导致突触蛋白SNAP25异常定位，从而引发认知功能障碍，为智力障碍疾病机制提供新依据。
2. **"Development of a monoclonal antibody for detecting DHHC9 in human cancer tissues"**
- 作者：Wang Y, et al.
- 摘要：报道了一种新型DHHC-9单克隆抗体的开发，通过免疫组化验证其在乳腺癌组织中的高表达，并发现DHHC-9表达水平与患者预后呈负相关。
3. **"DHHC9 antibody reveals dynamic subcellular localization during neuronal development"**
- 作者：Garcia-Ruiz A, et al.
- 摘要：利用DHHC-9特异性抗体结合共聚焦显微镜技术，揭示该蛋白在大鼠皮层神经元发育过程中从内质网向树突突触的动态迁移规律。
建议通过以下途径获取真实文献：
① PubMed中检索关键词 "DHHC9 antibody" + "palmitoylation";
② 关注《Journal of Biological Chemistry》《Cell Reports》等期刊近年相关论文。
The DHHC-9 antibody is a tool used to study the DHHC-9 protein, a member of the DHHC (Asp-His-His-Cys) family of palmitoyltransferases. These enzymes catalyze protein S-palmitoylation, a post-translational modification involving the attachment of palmitate fatty acids to cysteine residues, which regulates protein localization, stability, and interactions. DHHC-9. encoded by the ZDHHC9 gene, is localized to the Golgi apparatus and endoplasmic reticulum. It forms a functional complex with the Golgin protein GCP16 (GOLGA7) to mediate palmitoylation of specific substrates, including Ras family GTPases and synaptic proteins.
Research has linked DHHC-9 dysfunction to human diseases. Mutations in ZDHHC9 are associated with X-linked intellectual disability and neurodevelopmental disorders, likely due to impaired synaptic protein palmitoylation. Altered DHHC-9 expression has also been observed in cancers, suggesting roles in oncogenic signaling. The DHHC-9 antibody enables detection and characterization of the protein via techniques like Western blotting, immunofluorescence, and immunoprecipitation, aiding investigations into its enzymatic activity, substrate specificity, and interactions. Its development has advanced understanding of DHHC-9's contribution to cellular trafficking, neural connectivity, and disease mechanisms, making it a critical reagent for studying palmitoylation-dependent pathways in health and pathology.
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